Sort   by:  
 Page size 
GenomicsCombined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
PRJNA1195122 | ENA
TranscriptomicsControl shRNA- vs. obscurin shRNA-expressing MCF10A cells
Obscurins (~70-870kDa), encoded by the single OBSCN gene, are cytoskeletal proteins originally identified in striated muscles with structural and regulatory roles. Recently, analysis of 13,023 genes in breast and colorectal cancers identified OBSCN as one of the most frequently mutated genes, impli...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35494 | biostudies-arrayexpress
ProteomicsProteomic analysis of left ventricles containing the obscurin R4344Q mutation linked to hypertrophic cardiomyopathy and myocardia containing obscurin lacking Immunoglobulin domains 58/59 (Ig58/59)
Cardiac lysates prepared from left ventricles of 1-year-old female wild-type mice, mice carrying the obscurin R4344Q mutation, and mice carrying obscurin lacking the Ig58/59 domains (ΔIg58/59) were subjected to isobaric tandem-mass tagging, liquid chromatography, and mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2020-06-18 | PXD017314 | Pride
Arrhythmia R4344q mutation Obscurin Mus musculus Dilated cardiomyopathy Hypertrophic cardiomyopathy 
ProteomicsObscurin and Obsl1 functions for “Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
“Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.”
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013008 | Pride
Obscurin Obsl1 Sarcoplasmic reticulum organization Muscle metabolism Sarcolemmal integrity 
ProteomicsCombined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
Background: Muscle proteins of the obscurin protein family play important roles in sarcomere organization, sarcoplasmic reticulum (SR) and T-tubule architecture and function. However, their precise molecular functions and redundancies between protein family members as well as their involvement in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058697 | Pride
Mouse heart muscle itraq obscurin 
ProteomicsNew molecular insights into atrial fibrillation due to obscurin Ig58/59 deletion
Obscurins are giant, modular, cytoskeletal proteins that regulate striated muscle structure and function. Immunoglobulin domains 58/59 (Ig58/59) of obscurin interact with diverse proteins including titin variants and phospholamban. Mutations within Ig58/59 that alter these binding interactions have ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD028904 | Pride
Arrhythmia Z-disk Ca2+ cycling Obscurin Atrial fibrillation 
TranscriptomicsCombined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy.
RNAseq raw data generated from total cardiac RNA of cardiac specific Obscurin x Obsl1 knockout mice
ORGANISM(S): Mus musculus 
2025-02-01 | GSE283745 | GEO
UnknownExploring Obscurin and SPEG Kinase Biology.
Not available
S-EPMC7957886 | biostudies-literature
UnknownObscurin Maintains Myofiber Identity in Extraocular Muscles.
Not available
S-EPMC10860686 | biostudies-literature
UnknownObscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.
Not available
S-EPMC1885211 | biostudies-literature
Sort   by:  
 Page size