Alzheimer’s disease is characterized by neuropathological accumulation of amyloid plaques and neurofibrillary tangles composed of amyloid-beta peptides and hyperphosphorylated tau protein, respectively. These neuropathological changes alter the function of neurons, including synaptic contacts betwee...
Five young (2-month-old) and five aged (24-month-old) mouse brains were bisected along the midline to separate the right and left hemispheres, then snap-frozen in liquid nitrogen. The frozen tissues were pulverized using a Multi-Beads Shocker (Yasui Kikai) and stored at -150°C until further use.
Th...
To reveal a brain proteomic signature of chronic kidney disease in mice, we performed a mass spectrometry using a sarkosyl (detergent buffer)-insoluble fraction.
Xanthomonas campestris pv. campestris (Xcc) B100 is a phytopathogenic bacterium, which uses xanthan, a secreted heterogeneous exopolysaccharide in both stages of infection of Brassicaceae. Until now, proteome analysis of Xcc lacking a detailed view on the proteins involved in xanthan biosynthesis. P...
ORGANISM(S): Xanthomonas campestris pv. campestris str. B100
Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and spinal ant...
