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ProteomicsAnalysis of SARS-CoV-2 S protein by LC-MS
Analysis of disulfide bonds for SARS-Cov-2 S protein by LC-MS
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2020-09-09 | PXD019939 | Pride
Sars-cov-2 s disulfide lc-ms 
ProteomicsAnalysis of SARS-CoV-2 S protein by LC-MS
Analysis of disulfide bonds for SARS-Cov-2 S protein by LC-MS
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2021-06-08 | PXD026560 | Pride
Sars-cov-2 s disulfide lc-ms 
ProteomicsDifferential interferon-α subtype immune signatures suppress SARS-CoV-2 infection
Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies and have been successfully employed for the treatment of viral diseases. Humans express twelve IFN-alpha (α) subtypes, which activate downstream signall...
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD026079 | Pride
Isg Sars-cov-2 Antiviral treatment Therapy Covid-19 Type i ifn Ifnα subtypes 
ProteomicsRole of the internal disulfide bond in altering the binding properties of SARS-CoV-2 membrane binding peptide to lipid bilayer
The SARS-CoV-2 spike protein’s membrane-binding domain bridges the viral and host cell membrane, a critical step in triggering membrane fusion. we investigate how the SARS-CoV-2 spike protein interacts with host cell membranes, focusing on a membrane-binding peptide (MBP) located near the TMPRSS2 cl...
ORGANISM(S): Coronaviridae sp. 
2025-05-07 | PXD057533 | Pride
Membrane binding peptide Sars-cov-2 Cholesterol Disulfide bond 
ProteomicsSND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2 RNAs. We find that the host protein SND1 binds the 5ʹ end o...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD037528 | Pride
Sars-cov-2 Rna-binding proteins Rna interactome 
ProteomicsDeamidation drives molecular aging of the SARS-CoV-2 spike receptor-binding motif
The spike is the main protein component of the SARS-CoV-2 virion surface. The spike receptor-binding motif mediates recognition of the hACE2 receptor, a critical infection step, and is the preferential target for spike-neutralizing antibodies. Post-translational modifications of the spike receptor-b...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-02-17 | PXD027873 | Pride
Sars-cov-2 Molecular aging Rbd Deamidation 
ProteomicsDeamidation drives molecular aging of the SARS-CoV-2 spike receptor-binding motif
The spike is the main protein component of the SARS-CoV-2 virion surface. The spike receptor-binding motif mediates recognition of the hACE2 receptor, a critical infection step, and is the preferential target for spike-neutralizing antibodies. Post-translational modifications of the spike receptor-b...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-02-15 | PXD028071 | Pride
Sars-cov-2 Molecular aging Rbd Deamidation 
ProteomicsTMPRSS2-mediated coronavirus spike activation and inhibition
The human protease TMPRSS2 facilitates entry of many respiratory viruses into cells, including coronaviruses and influenza viruses, yet its mechanism or viral glycoprotein recognition remains unclear. Here, we show that following ACE2 engagement and formation of an early fusion intermediate SARS-CoV...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD069687 | Pride
Sars-cov-2 
UnknownE. coli production of a multi-disulfide bonded SARS-CoV-2 Omicron BA.5 RBD exhibiting native-like biochemical and biophysical properties.
Not available
S-EPMC10850476 | biostudies-literature
ProteomicsSHIFTR enables the unbiased identification of proteins bound to specific RNA regions in transcriptomes of virus and host
RNA-protein interactions determine the cellular fate of RNA and are central to regulating gene expression outcomes in health and disease. To date, no method exists to identify the proteins bound to specific regions in endogenous RNAs in an unbiased fashion. Here, we develop SHIFTR (Selective RNase-H...
ORGANISM(S): Homo sapiens (Human) 
2024-01-18 | PXD044722 | Pride
Interactomes Rna-protein interactions Virus-host interactions Sars-cov-2 Rna-binding proteins 
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