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ProteomicsMS analysis of BCG and recombinant BCG "70C-RBD"
BCG and recombinant BCG "70C-RBD" were cultured in Sauton media. Culture filtrate and cells lysate were separated by SDS-PAGE. The bands at 40kDa and 60kDa were excised and proteins were reduced and alkylated. In-gel digestion (Trypsin) was performed. The samples were analyzed by TripleTOF5600+ conj...
ORGANISM(S): Cellular Organisms 
2023-12-07 | PXD046929 | JPOST Repository
GenomicsMosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses
Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses
PRJNA1005917 | ENA
ProteomicsGlobal population analysis of HLA class I affinity toward proteasome-generated peptides from five main SARS-CoV-2 spike protein RBD variants
Here we report binding index of 305 human HLA class I molecules from 18,771 unique haplotypes of 28,104 individuals to the 821 peptides experimentally observed from spike protein receptor-binding domain (RBD) of 5 main SARS-CoV-2 strains hydrolysed by human proteasomes with constitutive and immuno c...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2025-01-29 | PXD050265 | Pride
Sars-cov-2  proteasome  immunoproteasome  hla class i  ifnγ 
ProteomicsImpact of mutations on the plant-based production of recombinant SARS-CoV-2 RBD
Recombinant RBD variants from SARS-CoV-2 spike were produced by transient expression in Nicotiana benthamiana plants and purified. The purified proteins were digested with proteases and glycopeptides were analysed by MS to identify the N-glycan structures.
ORGANISM(S): Nicotiana benthamiana 
2024-01-26 | PXD044462 | Pride
Glycosylation Virus Glycoprotein Vaccine Antigen Nicotiana benthamiana Spike protein 
ProteomicsBinding of a bovine ultralong CDRH3 to the SARS-CoV RBD
Here, we have used a SARS-naïve, bovine ultralong CDRH3 library to isolate a bovine paratope that engages the SARS-CoV and SARS-CoV-2 receptor-binding domain (RBD). This scFv (B9-scFv) neutralises viruses pseudo-typed with SARS-CoV Spike protein. Using differential hydrogen-deuterium exchange mass s...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-11 | PXD032965 | Pride
Human Sars-cov Antibody 
TranscriptomicsPeripheral Blood Mononuclear Cell Electrophysiology as a Marker for Immune Response to Exposure and Vaccination
Comparison of cell stimulated with SARS-CoV-2 RBD, peptide mix or control. Samples from 3 donors post second vaccine dose.
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14606 | biostudies-arrayexpress
TranscriptomicsMosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses
Universal vaccines cross-protecting against sarbecoviruses including SARS-CoV-2 are in great need under continuous emergence of SARS-CoV-2 variants and potential novel coronavirus. Nanoparicle vaccines displaying mosaic receptor-binding domains (RBDs) or spike (S) proteins from SARS-CoV-2 and other ...
ORGANISM(S): Mus musculus 
2024-05-12 | GSE240940 | GEO
TranscriptomicsGene expression profiling of human pancreatic cancer cells treated with RRSP-RBD-TAT and RRSP-TAT compared with untreated controls
Human pancreatic cancer cells (PANC-1) were treated with a protein-based pan-RAS inhibitor (RRSP-RBD-TAT), a control construct (RRSP-TAT), or vehicle control. After 48 hours of treatment, total RNA was extracted and subjected to gene expression profiling using Agilent SurePrint G3 Human GE 8x60K mic...
ORGANISM(S): Homo sapiens 
2026-05-02 | E-MTAB-16847 | biostudies-arrayexpress
ProteomicsDifferential Proteomic Landscape of Plasma Neuron-Derived Extracellular Vesicles in Parkinson’s Disease with and without RBD
Parkinson’s disease (PD) is increasingly recognized as a heterogeneous disorder, with rapid eye movement sleep behavior disorder (RBD) serving as a key prodromal marker for a distinct, aggressive subtype. This study investigates the plasma neuron-derived extracellular vesicle (EV) proteome to deline...
ORGANISM(S): Homo sapiens (Human) 
2026-08-27 | PXD076025 | Pride
Neuron-derived extracellular vesicle Α-synuclein Lipid metabolism Hetrogenity L1cam Rapid eye movement sleep behavior disorder (rbd) Proteomics Extracellular matrix remodeling Subtype stratification Precision medicine Parkinson’s disease Biomarkers 
TranscriptomicsVaccine based on immune evasion mutations integrated RBD protein have broad protection against SARS-CoV-2 [mRNA-seq]
Variants of SARS-CoV-2 continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. Continued vaccination with vaccines based on the antigens of newly emerged variants does not necessarily result in long-lasting protection. Thus, there is an urgent need for ...
ORGANISM(S): Mus musculus 
2024-03-15 | GSE261311 | GEO
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