Sort   by:  
 Page size 
ProteomicsLoss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
In mammals, RNA interference (RNAi) is mostly studied as a cytoplasmic event, however, numerous reports convincingly show nuclear localization of the AGO proteins. Nevertheless, the mechanism of nuclear entry remains to be fully elucidated, and the extent of nuclear RNAi further explored. We found t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD042899 | Pride
Y393-ago2 Argonaute 2 Lamin a Gene regulation Src Rna interference Fam120a Egfr 
ProteomicsIntegrative transcriptomic and proteomic profiling of the effects of cell confluency on gene expression
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a consequence of cell confluency, AGO2 protein translocates into the nucleus. Therefore, we ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD047707 | Pride
Cell density Cell confluence Par-clip Rna interference Mass spectrometry Gene regulation Rna sequencing 
Sort   by:  
 Page size