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TranscriptomicsLoss of Lamin A leads to nuclear translocation of AGO2 mediated by EGFR signaling and inactivation of RNAi
In mammals, RNA interference (RNAi) is mostly studied as a cytoplasmic event, however, numerous reports convincingly showed nuclear localization of AGO proteins. Nevertheless, the mechanism of the nuclear entry remains to be fully elucidated, and the extent of nuclear RNAi explored. The nuclear impo...
ORGANISM(S): Homo sapiens 
2023-06-22 | GSE235156 | GEO
UnknownArgonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS-driven malignancies.
Not available
S-EPMC9338400 | biostudies-literature
UnknownNew roles for nuclear EGFR in regulating the stability and translation of mRNAs associated with VEGF signaling.
Not available
S-EPMC5734708 | biostudies-literature
GenomicsLoss of Lamin A leads to nuclear translocation of AGO2 mediated by EGFR signaling and inactivation of RNAi
Loss of Lamin A leads to nuclear translocation of AGO2 mediated by EGFR signaling and inactivation of RNAi
PRJNA984679 | ENA
ProteomicsLoss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference
In mammals, RNA interference (RNAi) is mostly studied as a cytoplasmic event, however, numerous reports convincingly show nuclear localization of the AGO proteins. Nevertheless, the mechanism of nuclear entry remains to be fully elucidated, and the extent of nuclear RNAi further explored. We found t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD042899 | Pride
Y393-ago2 Argonaute 2 Lamin a Gene regulation Src Rna interference Fam120a Egfr 
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