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ProteomicsUrinary Glycoproteomic profiling of Non-Muscle Invasive and Muscle Invasive Bladder Carcinoma Patients reveals distinct N-glycosylation pattern of CD44, MGAM and GINM1
Clinical management of bladder carcinomas (BC) remains a major challenge and demands comprehensive multi-omics analysis for better stratification of the disease. Identification of patients on risk requires identification of signatures predicting prognosis risk of the patients. Understanding the mole...
ORGANISM(S): Homo sapiens (Human) 
2020-09-10 | PXD020078 | Pride
Urothelial carcinoma  n-linked glycoproteomics  urine proteomics  nmibc  mibc 
UnknownN-Glycoproteomic Profiling Reveals Alteration In Extracellular Matrix Organization In Non-Type Bladder Carcinoma.
Not available
S-EPMC6780497 | biostudies-literature
ProteomicsMechanism of degrader-targeted protein ubiquitinability
Small molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically stable and kinetically long-lived degrader-mediated ternary complexes can drive faster, more profound...
ORGANISM(S): Homo sapiens (Human) 
2024-11-08 | PXD053502 | Pride
Mz1 Vhl Ubiquitination 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD065740 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD065731 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065760 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065750 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065662 | Pride
Central nervous system Targeted protein degradation Direct-to-biology Glycogen synthase kinase 3 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065722 | Pride
Central nervous system Targeted protein degradation Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065724 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
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