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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
TranscriptomicsGene expression data from undifferentiated mouse embryonal carcinoma cell strains (MOE430A and MOE430B)
Gene expression profiles of undifferentiated mouse embryonal carcinoma cell strains (P19, P19CL6, and 4 P19CL6 sublines) were obtained, using Affymetrix GeneChip Mouse Genome 430A and 430B. Heart diseases such as cardiac infarction damage cardiomyocytes and consequently lead to significant loss of t...
ORGANISM(S): Mus musculus 
2011-01-26 | E-GEOD-26875 | biostudies-arrayexpress
ProteomicsThe proteomic analysis of SAMR1 and SAMP8 hippocampi and serum
We performed proteomic analysis of serum and hippocampal tissue from senescence-accelerated mouse-prone 8 (SAMP8) and senescence-accelerated mouse-resistant 1 (SAMR1) mice.
ORGANISM(S): Mus Musculus (mouse) 
2026-01-19 | PXD066582 | JPOST Repository
ProteomicsCross-linking MS analysis of HIV-2 Vpx-PHD3 protein interaction
This dataset presents chemical crosslinking mass spectrometry (CL-MS) analysis of protein-protein interactions between HIV-2 Vpx and PHD3. The experimental data includes MS spectra obtained from protein complexes comprising recombinant Vpx and PHD3 crosslinked using DSBU under physiological conditio...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059241 | JPOST Repository
ProteomicsPHD3-mediated HIV-2 Vpx peptide hydroxylation
This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset...
ORGANISM(S): Human Immunodeficiency Virus 2 
2025-04-03 | PXD059242 | JPOST Repository
ProteomicsProteome analysis of muscle, liver, and blood samples associated with cancer cachexia
We analyzed samples from multiple mouse cancer cacheixa modles and human gastric cancer patients by quantitative proteomics and protein acylation profiling.
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2023-08-04 | PXD035832 | JPOST Repository
ProteomicsProteome analysis of liver samples associated with cancer cachexia_sex
We analyzed samples from multiple mouse cancer cacheixa modles by quantitative proteomics.
ORGANISM(S): Mus Musculus (mouse) 
2023-08-04 | PXD042807 | JPOST Repository
ProteomicsAnalysis of exosomes released from cancer-associated glycosphingolipid-expressing cancer cells
In order to study the mechanism by which GD3/GD2-containing EVs released from gliomas in the actions toward target cells, we performed proteome analysis of EVs with/without GD3/GD2.
ORGANISM(S): Homo Sapiens (human) 
2025-10-15 | PXD056795 | JPOST Repository
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