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MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
TranscriptomicsTranscription profiling of peripheral blood mononuclear cells in healthy young men 6 hours after intake of either saturated fatty acids or polyunsaturated fatty acids
Acute effects of different dietary fatty acids on the gene expression profiles of peripheral blood mononuclear cells in healthy young men. A randomized cross-over study.
ORGANISM(S): Homo sapiens 
2009-11-01 | E-MTAB-65 | biostudies-arrayexpress
MetabolomicsEffect of probiotics intervention on short chain fatty acids in irradiated mice

In order to study the effect of probiotic intervention on short-chain fatty acids in irradiated mice, we collected feces, blood, and brain tissues from irradiated mice. The content of short-chain fatty acids was determined by High Performance Liquid Chromatography-mass spectrum. Further investiga...

2026-09-28 | MTBLS15754 | MetaboLights
TranscriptomicsHigh fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects
Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression cha...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-53232 | biostudies-arrayexpress
TranscriptomicsRNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids
Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids in seed triacylglycerols, however total seed oil is also reduced up to 50%. Investigations into the cause of the reduced oil phenotype through in vivo [14C]acteate and [3...
ORGANISM(S): Arabidopsis thaliana 
2014-01-10 | E-GEOD-53952 | biostudies-arrayexpress
MetabolomicsEffect of transplantation of irradiated mouse feces on blood short chain fatty acids in recipient mice
In order to study the effect of transplantation of irradiated mouse feces on the short chain fatty acids in the blood of recipient mice, we used mobile phones to transplant the feces of donor mice from 1W to 4W after irradiation. After 2W of antibiotic intervention, fecal bacteria were transplanted ...
2026-09-28 | MTBLS15752 | MetaboLights
TranscriptomicsInfluence of Fatty Acid Diets on Gene Expression in Rat Mammary Epithelial Cells
Background: This study examines the impact of dietary fatty acids on regulation of gene expression in the mammary epithelial cells before and during puberty. Methods: The diets primarily consisted of n-9 monounsaturated fatty acids (olive oil), n-6 polyunsaturated fatty acids (safflower), saturated ...
ORGANISM(S): Rattus norvegicus 
2009-04-01 | E-GEOD-14933 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart.
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30495 | biostudies-arrayexpress
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