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TranscriptomicsMicrocolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation.
A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the human pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant bi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-04-30 | E-GEOD-35286 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
UnknownProtein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Not available
S-EPMC3189067 | biostudies-literature
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
TranscriptomicsRNAseq analysis of murine ITPKB deficient versus wild type LT-HSC
Tight regulation of hematopoietic stem cell (HSC) homeostasis is essential for life-long hematopoiesis, for preventing blood cancers and for averting bone marrow failure. The underlying mechanisms are incompletely understood. Here, we identify production of inositol-tetrakisphosphate (IP4) by inosit...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56613 | biostudies-arrayexpress
UnknownExpression of the Methanobacterium thermoautotrophicum hpt gene, encoding hypoxanthine (Guanine) phosphoribosyltransferase, in Escherichia coli.
Not available
S-EPMC93603 | biostudies-literature
UnknownCognitive processes of ingroup favoritism across 20 countries: An eye-tracking investigation of culture, behavior, and cognition.
Not available
S-EPMC12358900 | biostudies-literature
ProteomicsGlobal coordination of metabolic pathways in Escherichia coli by active and passive regulation
In this study, we identify the regulatory mechanisms that coordinate catabolism and anabolism in the bacterium Escherichia coli. Integrating protein, metabolite, and metabolic flux changes in genetically implemented gradual catabolic or anabolic limitations, we show that a combination of global and ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2021-03-03 | MSV000086992 | MassIVE
UnknownBacterial Glycogen Provides Short-Term Benefits in Changing Environments.
Not available
S-EPMC7170487 | biostudies-literature
UnknownClassification and identification of bacteria by mass spectrometry and computational analysis.
Not available
S-EPMC2475672 | biostudies-literature
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