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TranscriptomicsMicrocolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation.
A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the human pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant bi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-04-30 | E-GEOD-35286 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
TranscriptomicsAnalysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
Alginate overproduction by P. aeruginosa, also known as mucoidy is associated with chronic endobronchial infections in cystic fibrosis (CF). Alginate biosynthesis in this bacterium is initiated by the extracytoplasmic function sigma factor (σ22, AlgU/T). In the wild type (wt) nonmucoid strains, su...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-01 | E-GEOD-35248 | biostudies-arrayexpress
UnknownAssessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia.
Not available
S-EPMC12308091 | biostudies-literature
UnknownAssociations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease.
Not available
S-EPMC12209746 | biostudies-literature
UnknownReal-world experience with biosimilar infliximab-adba and infliximab-dyyb among infliximab-naive patients with inflammatory bowel disease in the Veterans Health Administration.
Not available
S-EPMC11404896 | biostudies-literature
UnknownDisease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis.
Not available
S-EPMC8928597 | biostudies-literature
UnknownThe swine IsoLoop model of the gut host-microbiota interface enables intra-animal treatment comparisons to advance 3R principles.
Not available
S-EPMC12562777 | biostudies-literature
UnknownDevelopment and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.
Not available
S-EPMC12750132 | biostudies-literature
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