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Genomicsena-DATASET-ICR-PTGT-28-07-2015-16:51:33:172-264 - samples
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAD00001001452 | EGA
GenomicsAnaplastic oligodendroglioma exome and RNA sequencing data
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAS00001001209 | EGA
GenomicsMolecular and Population Genetics (MPG) research at ICR DAC and POLA DAC
Data Access Committee EGAC00001000328
EGAC00001000328 | EGA
UnknownMetformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19.

Aims

Metformin exerts anti-inflammatory and immunosuppressive effects. We addressed the impact of prior metformin use on prognosis in patients with type 2 diabetes hospitalised for COVID-19.

Methods

CORONADO is a nationwide observational study that included patients with diabetes hosp...
S-EPMC7832745 | biostudies-literature
UnknownOmega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study.
Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular, and immune function, as well as physical performance and bone health in older adults. So far, few studies have investigated the associations between PUFA status and performance-based tests ...
S-EPMC5636774 | biostudies-literature
UnknownLow circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults.
The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk for cognitive decline in the Multidomain Alzheimer Preventive Trial (ClinicalTrials.gov Identifie...
S-EPMC10828274 | biostudies-literature
UnknownPlasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults.

Background

Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are associated with cognitive and gait speed decline, relationships of combined plasma Aβ and NfL profiles with cognitive and physical function...
S-EPMC7545881 | biostudies-literature
UnknownInvestigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults.
We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Aβ] 42/40) with five plasma markers of inflammation, cellular stress, and neurodegeneration to predict cognitive decline. Among 401 participants free of dementia (median [IQR] age, 76 [73-80] years) from the ...
S-EPMC9213609 | biostudies-literature
UnknownPlasma neurofilament light chain is associated with cognitive decline in non-dementia older adults.
Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidom...
S-EPMC8238930 | biostudies-literature
UnknownPlasma MCP-1 and changes on cognitive function in community-dwelling older adults.

Background

Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition-Aβ42/40...
S-EPMC8742409 | biostudies-literature
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