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TranscriptomicsTranscriptome of Primitive Human Hematopoietic Cells: A New Resource to Find hHSC-Specific Genes
We analysed the transcriptome of different HSC-enriched subpopulations of cells sorted from human umbilical cord blood and isolated from several individuals with different genetic backgrounds. We aim at identifying new cell surface markers associated with human HSC and downstream mature hematopoieti...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-48846 | biostudies-arrayexpress
ProteomicsDDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition
In efforts to identify additional therapeutic targets for Acute Myeloid Leukemia (AML), we performed a high-throughput screen that includes 56 primary specimens tested with 10,000 structurally diverse small molecules. One specific hit, called S656 acts as a molecular glue degrader (MGD), that mediat...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD061850 | Pride
Molecular glue degrader Cdk12 Ddb1 Cyclin k Acute myeloid leukemia 
ProteomicsLarge scale screens of small molecules using multiple sources of human acute leukemia cells reveal novel targeting strategies
Useful targeted therapeutics for high risk subgroups of acute leukemia remain an unmet medical need. Here we report the results of a large-scale screening strategy that tested thousands of compounds targeting many signalling pathways for their ability to inhibit the survival and growth in vitro of h...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD040772 | Pride
Acute leukemia 
TranscriptomicsTrans-chromosomal regulation by a novel lincRNA required for adipogenesis that escapes X-chromosome inactivation
Long noncoding RNAs (lncRNAs) have emerged as an important layer of genome regulation with common mechanistic themes including the formation of ribonucleoprotein complexes. Here, we present a novel X-linked lncRNA termed linc-Firre that escapes X-chromosome inactivation and forms trans-chromosomal i...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45157 | biostudies-arrayexpress
TranscriptomicsRNA-Seq characterization of select lincRNA knockout mouse models
It has become clear that long intergenic noncoding RNAs (lincRNAs) are an important layer of genome regulation. Thousands have been identified in mammals, yet only a few have been tested through genetic ablation in animal models. Of the few that have, many yields weak to unobservable phenotypes, rai...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-49581 | biostudies-arrayexpress
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