Sort   by:  
 Page size 
TranscriptomicsInhibitory Actions of Anti-MM-CM-
The current study was designed to investigate the actions of Anti-MM-CM-
ORGANISM(S): Rattus norvegicus 
2011-03-04 | E-GEOD-25629 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestatin...
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59277 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Somatic Transcriptomes
Environmentally induced epigenetic transgenerational inheritance of adult onset disease involves a variety of phenotypic changes suggesting a general alteration in genome activity. Investigation of eleven different tissue transcriptomes in male and female F3 generation vinclozolin versus control l...
ORGANISM(S): Rattus norvegicus 
2012-06-30 | E-GEOD-35839 | biostudies-arrayexpress
TranscriptomicsGene Bionetworks Involved in Epigenetic Transgenerational Inheritance of Environmentally Altered Sexual Selection: Role of Epigenetics in Evolutionary Biology
Sexual selection involves mate preference behavior and is a critical determinant for natural selection and evolutionary biology. Previously an environmental compound (fungicide vinclozolin) was found to promote epigenetic transgenerational inheritance of modified mate selection characteristics in al...
ORGANISM(S): Rattus norvegicus 
2012-03-01 | E-GEOD-33830 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility [NimbleGen]
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The current study was designed to determine the impact of an altered sperm epigenome on the subsequent development of an adult somatic...
ORGANISM(S): Rattus norvegicus 
2014-07-07 | E-GEOD-59109 | biostudies-arrayexpress
TranscriptomicsInduction of Ovarian Primordial Follicle Assembly by Connective Tissue Growth Factor CTGF
Primordial follicle assembly is a process that occurs in the embryonic or early post natal ovary in which oocyte nests break down to form individual primordial follicles. The size of this initial pool of primordial follicles in part determines the reproductive lifespan of the female. Connective ti...
ORGANISM(S): Rattus norvegicus 
2010-09-16 | E-GEOD-22096 | biostudies-arrayexpress
TranscriptomicsAlterations in the developing testis transcriptome following embryonic vinclozolin exposure
The current study investigates the direct effects of in utero vinclozolin exposure on the developing rat testis transcriptome. Vinclozolin is a commonly used fungicide in agriculture and is an endocrine disruptor with anti-androgenic activity. Previous studies have demonstrated that exposure to vinc...
ORGANISM(S): Rattus norvegicus 
2010-02-24 | E-GEOD-20245 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The exposure of a gestating female during the period of gonadal sex determination has been shown to promote sperm epimutations, diffe...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-41173 | biostudies-arrayexpress
TranscriptomicsBasic helix-loop-helix transcription factor Tcf21 is downstream target of male sex-determining gene SRY
The cascade of molecular events involved in mammalian sex determination has been shown to involve the SRY gene, but specific downstream events have eluded researchers for decades. The current study identifies one of the first direct downstream targets of the male sex-determining factor SRY as the b...
ORGANISM(S): Rattus norvegicus 
2011-04-25 | E-GEOD-24666 | biostudies-arrayexpress
Sort   by:  
 Page size