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TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
ProteomicsThe role of ptpn21 in hematopoietic stem cells
To identify the downstream substrate/effector that mediates Ptpn21 function. We applied comprehensive phosphoproteomics analysis with Lin- cells isolated from Ptpn21-/- and Ptpn21+/+ mice. The analysis revealed many pTyr sites on molecules associated with cytoskeleton. Additionally, we present a lis...
ORGANISM(S): Mus Musculus 
PXD011381 |
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
ProteomicsPulsed SILAC study of cell lines following PPIA knockdown
Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spec...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-16 | MSV000093125 | MassIVE
UnknownA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate.
Not available
S-EPMC10957094 | biostudies-literature
ProteomicsTMT isobaric profiling of PPIA heterozygous versus knockout haematopoietic stem cells
Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spec...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-16 | MSV000093127 | MassIVE
ProteomicsTMT isobaric profiling of young versus old haematopoietic stem cells
Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spec...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-10-16 | MSV000093126 | MassIVE
ProteomicsPeptidylprolyl isomerase A (PPIA) protein complex
Identification of PPIA protein complex using wild type and mutant cell lines.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-27 | MSV000083867 | MassIVE
ProteomicsMouse Bone Marrow Proteome Profiling
Hematopoietic stem cells give rise to all blood lineages, can fully re-populate the bone marrow, and easily outlive the host organism. To better understand how stem cells remain fit during aging, we analyzed the proteome of hematopoietic stem and progenitor cells.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-05-23 | MSV000083845 | MassIVE
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