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TranscriptomicsTranscription profiling of human sensitive and resistant tumours identify gene expression patterns in primary breast-cancer specimens that might predict response to taxanes.
These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume.
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-349 | biostudies-arrayexpress
TranscriptomicsGene Bionetwork Analysis of Ovarian Primordial Follicle Development
Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth...
ORGANISM(S): Rattus norvegicus 
2010-06-13 | E-GEOD-20324 | biostudies-arrayexpress
TranscriptomicsA Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle
Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication betwe...
ORGANISM(S): Mus musculus 
2008-03-14 | E-GEOD-10785 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Muscle tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Muscle from 319 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/...
ORGANISM(S): Mus musculus 
2006-07-06 | E-GEOD-3088 | biostudies-arrayexpress
TranscriptomicsExpression profiling of brain tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Brain from 249 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/H...
ORGANISM(S): Mus musculus 
2006-07-06 | E-GEOD-3087 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms underlying the metabolic changes induced by the Pro12Ala PPARγ2 variant in mice
The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARγ2) variant Pro12Ala in human populations has been widely debated. We demonstrate using a Pro12Ala knock-in model that on chow Ala/Ala mice are leaner, have improved insulin sensitivity and plasma lip...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-13305 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Adipose tissue from (C57BL/6J X C3H/HeJ)F2 mice on ApoE null backgrounds
The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age. Adipose from 295 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H...
ORGANISM(S): Mus musculus 
2006-07-07 | E-GEOD-3086 | biostudies-arrayexpress
TranscriptomicsProfiling of hypothalamus tissue from the F2 M16xICR mouse cross.
We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-13745 | biostudies-arrayexpress
TranscriptomicsA functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease
Microarray Analysis of Human Whole Blood and Intestinal Biopsy Samples from a Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Crohn’s Disease 329 Crohn's biopsies from multiple regions in the intestine of 87 anti TNFa refractory patients an...
ORGANISM(S): Homo sapiens 
2017-07-07 | E-GEOD-100833 | biostudies-arrayexpress
TranscriptomicsMapping the Genetic Architecture of Gene Expression in Human Liver
To uncover the genetic determinants affecting expression in a metabolically active tissue relevant to the study of obesity, diabetes, atherosclerosis, and other common human diseases, we profiled 427 human liver samples on a comprehensive gene expression microarray targeting greater than 40,000 tran...
ORGANISM(S): Homo sapiens 
2008-05-07 | E-GEOD-9588 | biostudies-arrayexpress
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