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TranscriptomicsExpression changes in the absence of miR-128 in striatal D1-receptor positive neurons
MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron specific microRNA miR-128 in Dopamine D1-receptor expressing neurons in the murine striatum (D1-MSNs) lead to increased neuronal excitability, locomotor hyperactivity...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-48813 | biostudies-arrayexpress
TranscriptomicsGene expression data from hippocampus, striatum, hypothalamus cortex, Drd2-MSNs and Drd1-MSNs in mice
Goal of the experiment: Analysis of gene expression changes in the cortex, striatum, hippocampus, hypothalamus, Drd2-MSNs and Drd1-MSNs of mice with a postnatal, neuron-specific ablation of GLP or G9a as compared to control mice. For microarray analysis, hippocampus, hypothalamus, cortex and striatu...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19402 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons and Drd2+ Medium Spiny Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13384 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, cocaine treatment
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13386 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, Motor Neurons, and Purkinje Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13387 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of striatal tissue of wild type and Ezh1/Ezh2 dKO mice at 6 weeks, 3 months, and 6 months
Normal brain function critically depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. The fidelity of neuronal specification is contingent upon the robustness of the transcriptional program that supports the neuron ty...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-84243 | biostudies-arrayexpress
GenomicsDetection and localization of surgically resectable cancers with a multi-analyte blood test
Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with clinically detected can...
EGAS00001002764 | EGA
UnknownDistinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a).
Not available
S-EPMC4795479 | biostudies-literature
UnknownInfections in children admitted with complicated severe acute malnutrition in Niger.
Not available
S-EPMC3714292 | biostudies-literature
TranscriptomicsAUTS2 confers transcriptional activation to PRC1 in the CNS (RNA-Seq)
Naturally occurring variations of Polycomb Repressive Complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, Autism Susceptibility Candidate 2 (AUTS2). While AUTS2 is often disrupted in patients with neuronal disorders, the underlying ...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-60410 | biostudies-arrayexpress
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