Sort   by:  
 Page size 
TranscriptomicsRNAseq analysis of murine ITPKB deficient versus wild type LT-HSC
Tight regulation of hematopoietic stem cell (HSC) homeostasis is essential for life-long hematopoiesis, for preventing blood cancers and for averting bone marrow failure. The underlying mechanisms are incompletely understood. Here, we identify production of inositol-tetrakisphosphate (IP4) by inosit...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-56613 | biostudies-arrayexpress
TranscriptomicsNon-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Non-coding sense and antisense germline transcription within the immunoglobulin heavy chain locus precedes V(D)J recombination and has been proposed to be associated with Igh locus accessibility, although its precise role remains elusive. However, no global analysis of germline transcription through...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40984 | biostudies-arrayexpress
TranscriptomicsHydrocortisone and Triiodothyronine Regulate Hyaluronate Synthesis in a Tissue–Engineered Human Dermal Equivalent through Independent Pathways
Hydrocortisone (HC) and triiodothyronine (T3) have both been shown to be capable of independently inhibiting hyaluronate (HA, hyaluronic acid) synthesis in a self-assembled human dermal equivalent (human dermal matrix). We sought to investigate the action of these two hormones in concert on extracel...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-56616 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of composite bone marrow from healthy humans to investigate age related gene expression changes
Human bone marrow is a complex, diversified and well-organized hematopoietic network changing composition with age. The purpose of this study was to analyze variations in relative precursor B cell abundance in bone marrow with age by means of global gene expression profiling. RNA was isolated from c...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-11504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Kir6.1-deficient heart following LPS challenge
KATP opposes depolarization of cells in the heart, smooth muscle, and other tissues by permitting the efflux of potassium ions and this efflux is evidently required to prevent unopposed vasoconstriction and insufficiency of coronary artery blood flow triggered by one or more cytokines induced in res...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7605 | biostudies-arrayexpress
Sort   by:  
 Page size