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TranscriptomicsArray-based resequencing of human mitochondrial disease patient samples to identify rare DNA variants
This is a custom Affymetrix resequencing array for DNA sequencing of the entire coding region and exon-splice sites of 39 human genes (452 exons; 106,337 bases). These nuclear genes encode proteins localized to mitochondria and include known disease genes (i.e. POLG, C10orf2) and new candidate genes...
ORGANISM(S): Homo sapiens 
2011-08-26 | E-MTAB-346 | biostudies-arrayexpress
TranscriptomicsA functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system
Copper is an essential component of cytochrome C oxidase (i.e. complex IV of the electron transport chain), and is thus critical for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-23 | E-GEOD-47175 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of human WPMY-1 cells with PPARbeta/delta knock down and exposure to PPAR agaonists
Human WPMY-1 cells were depleted for PPARbeta/delta and exposed to the PPAR agonists GW501516.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2756 | biostudies-arrayexpress
GenomicsCTCF/CP190 and ISWI dependent regulation of nucleosome occupancy [ChIP-seq]
H3-ChIP-seq was performed in order to analyze changes in nucleosomal occupancy after depletion of CTCF/P190 and ISWI from Drosophila S2 cells Histone H3 ChIP-seq from Drosophila S2 cells after CTCF/CP190 or ISWI-specific RNAi treatment
ORGANISM(S): Drosophila melanogaster 
2014-08-11 | E-GEOD-51598 | biostudies-arrayexpress
GenomicsDifferential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and exon sequences
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41010 | biostudies-arrayexpress
GenomicsL3MBTL2 in HEK293 cells - ChIPseq
To elucidate the (possibly sumo dependent) binding sites of L3MBTL2, wild type L3MBTL2, L3MBTL2-Flag and L3MBTL2-KR-Flag ChIPs from HEK293 cells were analyzed via ChIPseq
ORGANISM(S): Homo sapiens 
2014-01-14 | E-MTAB-1731 | biostudies-arrayexpress
GenomicsLINT - a novel dL(3)mbt containing complex represses malignant brain tumour signature genes - sequencing data
dLint1 (CG1908) was ChIPseq`d in Drosophila melanogaster KC cells and S2 cells
ORGANISM(S): Drosophila melanogaster 
2012-06-27 | E-MTAB-855 | biostudies-arrayexpress
GenomicsGenome-wide identification of MBD2 and MBD3 binding sites by ChIP-seq
The heterogeneous collection of NuRD complexes can be grouped into the MBD2 or MBD3 containing complexes MBD2-NuRD and MBD3-NuRD. Although functional differences have been described, a direct comparison of MBD2 and MBD3 in respect to genome-wide binding and function has been lacking. Here we show a ...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41006 | biostudies-arrayexpress
GenomicsCTCF/CP190 and ISWI dependent regulation of nucleosome occupancy [MNase-seq]
MNase-seq was performed in order to analyze changes in nucleosomal occupancy after depletion of CTCF/P190 and ISWI from Drosophila S2 cells MNase-seq from Drosophila S2 nuclei after CTCF/CP190 or ISWI-specific RNAi treatment
ORGANISM(S): Drosophila melanogaster 
2014-08-11 | E-GEOD-51599 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells after MBD2 and MBD3 knock down
The heterogeneous collection of NuRD complexes can be grouped into the MBD2 or MBD3 containing complexes MBD2-NuRD and MBD3-NuRD. MBD2 is known to bind to methylated CpG sequences in vitro in contrast to MBD3. Although functional differences have been described, a direct comparison of MBD2 and MBD3 ...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-GEOD-41003 | biostudies-arrayexpress
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