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ProteomicsCEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion
The centriole-to-centrosome conversion is a mechanism of the centrosome maturation process that depends on the formation of a proper centriole wall structure. Beside the centriole wall biogenesis factors TUBD1 and TUBE1, CEP44 is involved in this process. Lack of CEP44 generates defects in the centr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD017332 | Pride
Human Centriol-to-centrosome conversion Poc1b Centrosome Cep44 
TranscriptomicsExpression profiling HeLa DOCK6 knockout clones 1 and 45 compared to wild type cells
We described a striking divergence between the phenotypes arising from acute (siDOCK6) and chronic (DOCK6 KO cells) depletion is highly suggestive of a suppression mechanism that buffers the prolonged absence of DOCK6. To identify the factor(s) that compensate for the lack of DOCK6 activity, we comp...
ORGANISM(S): Homo sapiens 
2016-09-29 | E-MTAB-5068 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of AOS Patient fibroblasts against Control fibroblasts
We described a striking divergence between the phenotypes arising from acute (siDOCK6) and chronic (DOCK6 KO cells) depletion is highly suggestive of a suppression mechanism that buffers the prolonged absence of DOCK6. This mechanism is probably also active in AOS patients who harbor homozygous loss...
ORGANISM(S): Homo sapiens 
2016-09-29 | E-MTAB-5067 | biostudies-arrayexpress
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