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UnknownNew functions of aminoacyl-tRNA synthetases beyond translation.
Not available
S-EPMC3042954 | biostudies-literature
ProteomicsMethionyl-tRNA synthetase interactome
During mRNA translation, tRNAs are charged by aminoacyl-tRNA synthetases (aaRS) and subsequently used by ribosomes. A multi-enzyme aminoacyl-tRNA synthetase complex (MSC) has long been proposed to increase protein synthesis efficiency by passing charged tRNAs directly to ribosomes. An alternative is...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD021527 | Pride
Aminoacyl-trna synthetases Multisynthethase complex 
ProteomicsCharacterizing the interactome of human Arginyl-tRNA Synthethase
Prior work revealed nuclear-localized aminoacyl-tRNA synthetases (aaRSs) that checked newly synthesized tRNAs for charging before export to the cytoplasm. To reveal other functions, we sought to identify nuclear proteins that interact with arginyl-tRNA synthetase (ArgRS) in the nucleus. Serine/Arg...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD015692 | Pride
Arginine Trna syntethase Trna 
ProteomicsMHCI peptidome of HepG2 with ArgRS or SRRM2 knock down
Cells respond to perturbations like inflammation by sensing changes in metabolite levels. Especially prominent is arginine, which has known connections to the inflammatory response. Here, we found that depletion of arginine during inflammation decreased levels of a nuclear form of arginyl-tRNA synth...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD036232 | Pride
Inflammation Mhci Peptidome 
ProteomicsN-terminomics upon Arginyl-tRNA synthetase knock down
Arginine is associated with inflammation, cancer, and amino acid signaling, in part through the mTORC1 pathway. In cell-based assays and in the mouse, we found that arginine regulates nuclear levels of arginyl-tRNA synthetase (ArgRS), and that arginine depletion and inflammation reduced nuclear ArgR...
ORGANISM(S): Homo sapiens (Human) 
2023-04-14 | PXD024091 | Pride
Trna Aminoacyl-trna synthetase Splicing N-terminomics 
UnknownMagnetic Hysteresis at 10 K in Single Molecule Magnet Self-Assembled on Gold.
Not available
S-EPMC7927621 | biostudies-literature
UnknownStructural switch of lysyl-tRNA synthetase between translation and transcription.
Not available
S-EPMC3766370 | biostudies-literature
UnknownCerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients.
Not available
S-EPMC7470445 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
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