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ProteomicsSchlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma
We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly, ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD021749 | Pride
Schlafen 5 Pancreatic ductal adenocarcinoma 
GenomicsSchlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery
Schlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery
PRJNA811597 | ENA
UnknownStructural and biochemical characterization of human Schlafen 5.
Not available
S-EPMC8789055 | biostudies-literature
GenomicsSchlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery
Schlafen-5 (SLFN5) is an interferon-induced protein of the Schlafen family which are involved in immune responses and oncogenesis. To date, little is known regarding its anti-HIV-1 function. Here, the authors report that overexpression of SLFN5 inhibits HIV-1 replication and reduces viral mRNA level...
ORGANISM(S): Homo sapiens 
2022-05-24 | GSE197700 | GEO
UnknownSchlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
Not available
S-EPMC9226525 | biostudies-literature
UnknownSchlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma.
Not available
S-EPMC8106654 | biostudies-literature
UnknownpiRNA processing by a trimeric Schlafen-domain nuclease.
Not available
S-EPMC10567574 | biostudies-literature
UnknownComprehensive analysis of bulk and single-cell RNA sequencing data reveals Schlafen-5 (SLFN5) as a novel prognosis and immunity.
Not available
S-EPMC11413889 | biostudies-literature
ProteomicspiRNA processing by a trimeric Schlafen-domain-containing nuclease
Transposable elements are genomic parasites that expand within and spread between genomes. Piwi proteins control transposon activity, notably in the germline. These proteins recognize their targets through small RNA co-factors named piRNAs, making piRNA biogenesis a key specificity-determining step ...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD039502 | Pride
Interactomics  lc-ms/ms 
UnknownHuman Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
Not available
S-EPMC7435190 | biostudies-literature
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