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TranscriptomicsIn-Vitro Cell Adhesion Assay
The adhesion of monocytic cells to the M-^SdysfunctionalM-^T endothelium constitutes a critical step in the initiation of atherosclerotic plaque formation. Cigarette smoke (CS) has been shown to contribute to the monocyte-endothelial adhesion process. Yet, the complex mechanisms underlying this even...
ORGANISM(S): Homo sapiens 
2014-04-24 | E-MTAB-1173 | biostudies-arrayexpress
TranscriptomicsHuman Organotypic Smoke Street
The aim of this study was to develop human bronchial and nasal epithelium culture models that are relevant to investigate the impact of cigarette smoke (CS) observed in vivo in respiratory tract tissues in contact with inhaled CS. We used two organotypic cultures generated from primary cells derive...
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-1721 | biostudies-arrayexpress
TranscriptomicsEffect of cessation after short term exposure to cigarette smoke
Modern 'omic' technologies, where changes in the expression of thousands of molecular species can be investigated in even a simple experiment, provide contemporary biomedical researchers with an unprecedented level of molecular granularity. An outstanding challenge is transformation of this experim...
ORGANISM(S): Mus musculus 
2013-02-15 | E-MTAB-1313 | biostudies-arrayexpress
TranscriptomicsNetwork Perturbation Amplitude on NHBE cells - Replication
Modern omics technologies, where changes in the expression of thousands of molecular species can be investigated in even a simple experiment, provide contemporary biomedical researchers with an unprecedented level of molecular granularity. An outstanding challenge is transformation of this experimen...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1312 | biostudies-arrayexpress
TranscriptomicsCell Proliferation Network Perturbation Measured in NHBE cells
Modern M-^QomicsM-^R technologies, where changes in the expression of thousands of molecular species can be investigated in even a simple experiment, provide contemporary biomedical researchers with an unprecedented level of molecular granularity. An outstanding challenge is transformation of this ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MTAB-1272 | biostudies-arrayexpress
TranscriptomicsAorta transcriptome of ApoE-/- mice exposed to mainstream cigarette smoke for 30 days.
Aorta gene expression profiles of smoke- and sham-exposed female ApoE-/- mice were analyzed to elucidate the biological networks perturbed by exposure to 600mg TPM/m3 for 4h per day, 5 days a week, for a period of 30 days. Aortic arches were dissected 24h after the last exposure.
ORGANISM(S): Mus musculus 
2015-01-12 | E-MTAB-1696 | biostudies-arrayexpress
TranscriptomicsAn application of a systems toxicology approach using a human organotypic small airway cultures for a comparative assessment between a candidate modified-risk tobacco product aerosol and cigarette smoke (mRNA data).
Along the trachea-bronchial tree, including the small airway region, cigarette smoke exposure induces inflammation, which can exacerbate the development of chronic obstructive pulmonary disease (COPD). The small airway region is known as the primary location of airway blockage in COPD and asthma. Th...
ORGANISM(S): Homo sapiens 
2017-10-26 | E-MTAB-6098 | biostudies-arrayexpress
TranscriptomicsAn application of a systems toxicology approach using a human organotypic small airway cultures for a comparative assessment between a candidate modified-risk tobacco product aerosol and cigarette smoke.
Along the trachea-bronchial tree, including the small airway region, cigarette smoke exposure induces inflammation, which can exacerbate the development of chronic obstructive pulmonary disease (COPD). The small airway region is known as the primary location of airway blockage in COPD and asthma. Th...
ORGANISM(S): Homo sapiens 
2017-10-26 | E-MTAB-6004 | biostudies-arrayexpress
TranscriptomicsStructural, Functional and Molecular Impact on the Cardiovascular System in ApoE-/- Mice Exposed to Aerosol from modified risk tobacco products, the Carbon Heated Tobacco Product 1.2 and the Tobacco Heating System 2.2 compared to Cigarette Smoke effects (mRNA data).
AIM: To investigate the molecular, structural, and functional impact of aerosols from two heat-not-burn-based MRTPs, the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of cigarette mainstream smoke (CS) on the cardiovascular system of ApoE-/- mice. ...
ORGANISM(S): Mus musculus 
2021-08-16 | E-MTAB-7980 | biostudies-arrayexpress
TranscriptomicsCigarette smoke exposure of human organotypic cultures of buccal and gingival mucosa
Oral mucosa of smokers is subject to cigarette smoke (CS)-related cytological, genomic, and transcriptional changes that could potentially lead to the development of mouth diseases. In order to further characterize CS effects, we took advantage of two human organotypic in vitro models of the buccal ...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-MTAB-2251 | biostudies-arrayexpress
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