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GenomicsGenomic landscape of IG-MYC positive Burkitt lymphoma with precursor B-cell immunophenotype.
As part of the ICGC, the ICGC MMML-Seq project performed whole genome sequencing of a rare Burkitt lymphoma subtype with precursor B-cell immunophenotype. Analysis were performed in concordance with the guidelines of the ICGC.
EGAS00001002968 | EGA
Genomics233fa72b-87ef-4a9b-b96d-dfb6ca9543bd - samples
This dataset contains the aligned whole genome sequencing data of cell line 380. This cell was established from the peripheral blood of a 15-year-old boy with acute lymphoblastic leukemia at relapse, showing an immature phenotype and carrying an IGH-MYC (t(8;14)) as well as an IGH-BCL2 (t(14;18)) ch...
EGAD00001004090 | EGA
TranscriptomicsDeregulation of the endogenous C/EBPM-NM-2 LIP isoform predisposes to tumorigenesis
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription factor CCAAT enhancer binding protein beta (C/EBPM-NM-2) are expressed from a single intronless Cebpb gene by alternative translation initiation. Isoform expression is sensitive to mammalian target of ...
ORGANISM(S): Mus musculus 
2014-12-16 | E-GEOD-53770 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse interleukin-10-deficient model for inflammatory bowel disease in C57Bl/6J and C3H/HeJBir strain backgrounds
Abstract: Interleukin-10-deficient (Il10-/-) mice serve as a model for inflammatory bowel disease (IBD). The severity of colitis strongly depends on the inbred strain carrying the disrupted Il10 gene: C3H/HeJBir (C3) confers disease susceptibility, whereas C57BL/6J (B6) confers resistance. Genome-wi...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2172 | biostudies-arrayexpress
TranscriptomicsTransient transfection of miR-449 family in the hepatocellular carcinoma cell line HLE
In this study, we comparatively analyzed the members of the miR-449 family (miR-449a, miR-449b, and miR-449c) with regards to their target genes and functional effects in hepatocellular carcinoma (HCC). Microarray analysis after transient transfection of miR-449a, miR-449b, and/or miR-449c in the HC...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-74710 | biostudies-arrayexpress
TranscriptomicsParthenogenetic stem cells for tissue-engineered heart repair
Uniparental parthenotes are considered an unwanted byproduct of in vitro fertilization. In utero parthenote development is severely compromised by defective organogenesis and in particular by defective cardiogenesis. Although developmentally compromised, apparently pluripotent stem cells can be deri...
ORGANISM(S): Mus musculus 
2013-02-23 | E-GEOD-30868 | biostudies-arrayexpress
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