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TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-03 | E-GEOD-29704 | biostudies-arrayexpress
TranscriptomicsRosR is a haloarchaeal-specific transcription factor required for the response to extreme oxidative stress in Halobacterium salinarum NRC-1.
Previous work has shown that the hypersaline-adapted archaeon, Halobacterium salinarum NRC-1, is highly resistant to oxidative stress caused by exposure to hydrogen peroxide, UV and gamma radiation. Genome-wide dynamics alteration of gene the GRN has been implicated in such resistance. However, the...
ORGANISM(S): Halobacterium sp. NRC-1 
2012-08-12 | E-GEOD-33980 | biostudies-arrayexpress
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-02 | E-GEOD-29705 | biostudies-arrayexpress
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon
This SuperSeries is composed of the following subset Series: GSE29704: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [gene expression data] GSE29705: Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data] R...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-02 | E-GEOD-29706 | biostudies-arrayexpress
TranscriptomicsA regulatory hierarchy controls the dynamic transcriptional response to extreme oxidative stress in archaea.
Previous work identified the winged helix-turn-helix DNA binding transcription factor (TF) RosR (encoded by VNG0258H gene), which dynamically regulates expression of more than 300 genes in response to oxidative stress in Halobacterium salinarum (Sharma 2012). RosR is required for survival of oxidant...
ORGANISM(S): Halobacterium sp. NRC-1 
2015-02-18 | E-GEOD-58696 | biostudies-arrayexpress
TranscriptomicsH. salinarum TrmB dynamics
Previous work characterized TrmB as a global glucose responsive metabolic transcription factor in archaeal extremophiles. However, it remains unclear how TrmB dynamically regulates its ~100 metabolic enzyme-coding genes. Using a dynamic perturbation approach, we elucidate the topology of the metabol...
ORGANISM(S): Halobacterium sp. NRC-1 
2013-08-07 | E-GEOD-47201 | biostudies-arrayexpress
TranscriptomicsHalobacterium salinarum NRC-1 VNG1451C transcription factor ChIP-chip with and without carbon sources
Gene regulatory networks play an important role in coordinating biochemical fluxes through diverse metabolic pathways. The modulation of enzyme levels enables efficient utilization of limited resources as organisms dynamically acclimate to nutritional fluctuations in their environment. Here we hav...
ORGANISM(S): Halobacterium sp. NRC-1 
2010-05-06 | E-GEOD-13498 | biostudies-arrayexpress
TranscriptomicsHalobacterium NRC-1 ura3 parent strain and VNG1451C deletion mutant in response to growth in rich medium
Gene regulatory networks play an important role in coordinating biochemical fluxes through diverse metabolic pathways. The modulation of enzyme levels enables efficient utilization of limited resources as organisms dynamically acclimate to nutritional fluctuations in their environment. Here we hav...
ORGANISM(S): Halobacterium sp. NRC-1 
2010-05-06 | E-GEOD-13531 | biostudies-arrayexpress
TranscriptomicsHalobacterium NRC-1 VNG1451C deletion mutant growth in defined medium with and without glucose
Gene regulatory networks play an important role in coordinating biochemical fluxes through diverse metabolic pathways. The modulation of enzyme levels enables efficient utilization of limited resources as organisms dynamically acclimate to nutritional fluctuations in their environment. Here we hav...
ORGANISM(S): Halobacterium sp. NRC-1 
2010-05-06 | E-GEOD-13529 | biostudies-arrayexpress
UnknownEnzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer.
Not available
S-EPMC5858523 | biostudies-literature
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