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MetabolomicsLipid Data Analyzer: Analysis of a complex biological system from murine liver samples (Murine liver lipidome experiment)
Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spectr...
2017-11-07 | MTBLS396 | MetaboLights
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
ProteomicsQuantitative proteomics reveals the role of arginine phosphorylation in bacterial stress response
Application of a novel TiO2-based phosphopeptide enrichment protocol to study the role of protein arginine phosphorylation in B.subtilis. 1 iTRAQ Quantification of pArg peptides in B.subtilis upon heat shock and oxidative stress in comparison to unstressed control 2 Studying pArg upon deletion of M...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-21 | PXD000273 | Pride
Stress response Arginine phosphorylation Bacillus subtilis 
TranscriptomicsTranscription profiling of fission yeast strains designed to make swi5-based mapping more efficient and powerful
Fission yeast genes identified in genetic screens are usually cloned by transformation of mutants with plasmid libraries. However, for some genes this can be difficult, and positional cloning approaches are required. The mutation swi5-39 reduces recombination frequency in homozygous crosses and ha...
ORGANISM(S): Schizosaccharomyces pombe 
2008-07-04 | E-TABM-517 | biostudies-arrayexpress
ProteomicsA quantitative proteomic analysis of in vitro assembled chromatin
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone prote...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-01-27 | PXD002537 | Pride
Acetylation  affinity proteomics  chromatin function or biology  label-free quantification   macromolecular assemblages 
ProteomicsIntricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation
In higher eukaryotes centromeres often coalesce into a large intranuclear domain called the chromocenter. Chromocenters are important for the organization of pericentric heterochromatin and a disturbance of their formation results in an upregulation of repetitive elements and causes defects in chrom...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-03-23 | PXD012551 | Pride
Chromatin proteomics Drosophila Chromocenter Centromeres 
ProteomicsMolecular effects of Vitamin C treatment in MSC80 cells, a suitable Schwann cell model
Schwann cells (SCs) are not only decisive to produce the axon-wrapping myelin sheath thus ensuring a proper nerve conduction but also exhibit with trophic function and can direct repair mechanisms of the peripheral nervous system. Consequently, suitable and well-characterized SC in vitro models are ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-13 | PXD006910 | Pride
Protein cataloguing Msc80 Tmx1 Schwann cells 
ProteomicsMuscular and molecular pathology associated with SPATA5-deficiency in a child with EHLMRS
Mutations in the SPATA5-gene are associated with the Epilepsy, Hearing Loss and Mental Retardation Syndrome (EHLMRS). While SPATA5 is ubiquitously expressed and is attributed a role in mitochondrial morphogenesis during spermatogenesis, there is only limited knowledge on the associated muscular and ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026182 | Pride
Ehlmrs  spata5  mitochondrial disorder  muscle proteomics  myopathology 
ProteomicsIdentification of a homozygous SCO2 variant in two siblings strengthens the concept of this gene being causative for early-onset axonal Charcot-Marie-Tooth neuropathy
The mitochondrial resident SCO2 protein acts as a copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Recessive mutations in the synthesis of cytochrome C oxidase 2 gene SCO2 were reported in several cases with fatal infantile cardioen...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD026283 | Pride
Protein sco2 homolog Rare diseases White blood cell proteomics Axonal neuropathy 
ProteomicsGiant Axonal Neuropathy (GAN): Cross-sectional data on phenotypes, genotypes and proteomics signature from a German-Austrian-Swiss cohort
Giant Axon Neuropathy (GAN) is a progressive neurodegenerative disease characterised by involvement of peripheral and central nervous system frequently associated with frizzy hair. The phenotype is caused by bi-allelic variants in the GAN gene, leading to loss of functional gigaxonin proteins.. Thus...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053070 | Pride
White blood cells Gan Proteomics 
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