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GenomicsThe histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 [ChIP-Seq]
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion ...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41172 | biostudies-arrayexpress
TranscriptomicsThe histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41174 | biostudies-arrayexpress
TranscriptomicsJarid1b targets genes regulating development and is involved in neural differentiation [expression array]
The H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for embryonic stem cell (ESC) self-renewal, but essential for ESC differentiation along the neural lineage. During neural differentiation, Jarid1b depleted ESCs fail to efficiently silence lineage-inappropriate genes, specifically...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31967 | biostudies-arrayexpress
GenomicsJarid1b targets genes regulating development and is involved in neural differentiation
This SuperSeries is composed of the following subset Series: GSE31966: Jarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq] GSE31967: Jarid1b targets genes regulating development and is involved in neural differentiation [expression array] Refer to indivi...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31968 | biostudies-arrayexpress
GenomicsJarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq]
We analyzed the genome-wide binding profile of Jarid1b in mouse ESCs. We find that Jarid1b localizes mainly to transcription start sites, of which more than 50% are also bound by Polycomb proteins and are enriched for genes encoding developmental regulators. Furthermore, we generated genome-wide map...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31966 | biostudies-arrayexpress
TranscriptomicsGene expression from head and neck squamous cell carcinoma (SCCHN) cancer cells before and after figitumumab
Patients with palliative SCCHN were treated with figitumumab, an IGF-1R inhibitor. This receptor plays an important role in cell growth, proliferation and differentiation and is often overexpressed in SCCHN. No significant clinical activity was observed in our study We used microarray to establish h...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-31287 | biostudies-arrayexpress
UnknownComparison of 6 handheld ultrasound devices by point-of-care ultrasound experts: a cross-sectional study.
Not available
S-EPMC11447175 | biostudies-literature
UnknownA biomarker assay to risk-stratify patients with symptoms of respiratory tract infection.
Not available
S-EPMC9753477 | biostudies-literature
TranscriptomicsmiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (mRNA)
MicroRNA (miRNA) expression profiling identified miR-638 as one of the most significantly overexpressed miRNAs in metastatic lesions compared with primary melanomas. miR-638 enhanced the tumourigenic properties of melanoma cells in vitro and lung colonization in vivo. mRNA expression profiling of mi...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-54493 | biostudies-arrayexpress
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