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ProteomicsProtein kinase C epsilon deletion in AgRP neurons modulates hypothalamic glucose sensing and improves glucose tolerance in mice
Total and phosphoproteomic analysis of liver and white adipose tissue from mice with specific deletion of protein kinase C epsilon in AgRP nerons of the hypothalamus, 30 min after i.p. injection with glucose.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD065137 | Pride
Glucose agrp neuron hypothalamus protein kinase c epsilon 
ProteomicsCell-Penetrant Peptides as Novel Inhibitors of the Interaction of Coatomer Protein COPB2/RACK2 with Protein Kinase Cε and Cargo Proteins
Type 2 Diabetes Mellitus (T2DM) is a multifactorial metabolic disorder characterised by insulin resistance and defective insulin secretion. The lipid-activated novel protein kinase C isoform, PKCε, has been shown to play a key role in the progression of T2DM; chronic activation of PKCε from lipid ov...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-15 | PXD065142 | Pride
Copb2 Type 2 diabetes Rack2 Protein kinase c epsilon Alphascreen Dilysine motif Peptide 
ProteomicsProteomic Analysis of Livers from Fat-fed Mice Deficient in Either PKCδ or PKCɛ
To investigate the mechanisms of lipid-activated protein kinase C (PKC) family, PKCδ or PKCɛ, involved in insulin resistance and fatty acid metabolism, we employed an in vivo adaptation of SILAC to examine the effects of a fat diet together with deletion of PKCδ or PKCɛ on the expression of liver pr...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-04 | PXD000971 | Pride
Insulin resistance Mouse Silac Liver Protein kinase c High-fat diet Fatty acid metabolism Glucose intolerance 
ProteomicsEffects of a protein kinase C epsilon inhibitor on insulin signalling in lipid-treated HepG2 hepatocytes and glucose tolerance in fat-fed mice
Protein kinase C epsilon (PKCe) has been shown to play a causative role in the generation of glucose intolerance and insulin resistance. Tissue-specific deletion of PKC indicates multiple sites of action, highlighting the kinase as a potential target for the treatment of type 2 diabetes. CIDD-015061...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-11 | PXD054895 | Pride
Dia Mouse Swath Lcms Liver 
TranscriptomicsA Global Approach to Dissect Palmitate-induced Impairment of Hepatic Glucose Production
Obesity-induced insulin resistance of the liver is characterised by increased gluconeogenesis, which contributes to elevated blood glucose levels in individuals with type 2 diabetes. Research into how fatty acids induce insulin resistance has commonly focused on the induction of insulin resistance. ...
ORGANISM(S): Rattus norvegicus 
2013-11-08 | E-GEOD-52204 | biostudies-arrayexpress
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