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TranscriptomicsLAA expression profiles on LSC compared to other tissues
Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. Leukemia associated antigens (LAA) might be suitable structures to be attacked by immunotherapeutic age...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-68172 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.
Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect ...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-GEOD-17046 | biostudies-arrayexpress
ProteomicsRNase L activating 2′-5′ oligoadenlyates bind ABCF1, -3 and Decr-1
Identification of 2′–5′ OA binding proteins in human (HeLa), mouse (BMDM) and fly (Schneider S2) cells using affinity purification mass spectrometry (AP-MS). Pulsed SILAC-based translational profiling in HeLa and HeLa S3 cells treated with 2′–5′ OA or OH-2′–5′ OA.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2023-08-18 | PXD030134 | Pride
Psilac Ap-ms Lc-ms/ms 
UnknownOncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression.
Not available
S-EPMC3323897 | biostudies-literature
GenomicsPolycomb preferentially targets stalled promoters of coding and non-coding transcripts
The Polycomb group (PcG) and Trithorax group (TrxG) of proteins are required for stable and heritable maintenance of repressed and active gene expression states. Their antagonistic function on gene control, repression for PcG and activity for TrxG, is mediated by binding to chromatin and subsequent ...
ORGANISM(S): Drosophila melanogaster 
2010-12-21 | E-GEOD-24521 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (RNAi)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30990 | biostudies-arrayexpress
UnknownsRNA154 a newly identified regulator of nitrogen fixation in Methanosarcina mazei strain Go1.
Not available
S-EPMC5785227 | biostudies-literature
TranscriptomicsThe activation potential of MOF is constrained for dosage compensation
The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila, but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter ...
ORGANISM(S): Drosophila melanogaster 
2010-06-26 | E-GEOD-20695 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
This SuperSeries is composed of the following subset Series: GSE30989: MOF-containing NSL complex specifically binds promoters of most, but stimulates only a specific subset of, housekeeping genes (ChIP-chip dataset) GSE30990: MOF-containing NSL complex specifically binds promoters of most, but stim...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30991 | biostudies-arrayexpress
UnknownInhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Not available
S-EPMC8689681 | biostudies-literature
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