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UnknownModulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity.
Not available
S-EPMC4209548 | biostudies-literature
MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
ProteomicsExploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer
The tumor microenvironment (TME) actively contributes to pancreatic ductal adenocarcinoma (PDAC) pathogenesis via a dynamic bidirectional tumor–stroma dialog. Here, we show that homologous recombination-defective (HRD) neoplastic epithelium reprograms its TME in a genotype-specific manner to promote...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD042750 | Pride
P53 Atm Tumor–stroma crosstalk Pancreatic ductal adenocarcinoma Personalized medicine Cancer-associated fibroblasts Tumor microenvironment 
UnknownRoom for Improvement: The HIV-Diabetes Care Continuum Over 15 Years in the Women's Interagency HIV Study.
Not available
S-EPMC6007350 | biostudies-literature
UnknownManagement of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Not available
S-EPMC6481621 | biostudies-literature
ProteomicsAffinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsP5-–Binding Proteins in Plants
Inositol pyrophosphates (PP-InsPs) are central regulators of eukaryotic signaling events. While certain PP-InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain containing proteins in plants, the functions of the recently discovered...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD073760 | Pride
Inositol pyrophosphates Plants Phosphate homeostasis 
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