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TranscriptomicsTranscriptome study of THP-1 human monocytes following exposure for 4 h or 24 h to 50 uM S-Nitrosoglutathione, 50 and 200 ug/ml S-Nitrosoglutathione-loaded polymeric and empty Eudragit RL nanoparticles
To further study the transcriptome of THP-1 human monocytes after exposure to S-Nitrosoglutathione (GSNO), we investigate whole genome microarray expression to identify genes regulated by exposure or not to GSNO. To further study the transcriptome of THP-1 human monocytes after exposure for 4 h to 5...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-51186 | biostudies-arrayexpress
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
TranscriptomicsChIP-chip from Kc cells with Su(H) antibodies after 30 minutes Notch activation
During hematopoiesis, Notch regulates both the emergence of stem and progenitor cells and the subsequent cell fate choices and differentiation. To investigate how Notch drives cells to differentiate we have used a genome-wide approach to identify direct Notch targets in Drosophila Kc cells. These da...
ORGANISM(S): Drosophila melanogaster 
2013-03-08 | E-GEOD-43132 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Drosophila Schneider cells using antibodies against HP1a
Preparation of nuclear extracts

D. melanogaster Schneider cells were prepared as previously described by Andrews and Faller (1991). Briefly, in a typical preparation, 8x106 cells (grown in Schneider medium plus 10% fetal calf serum; GIBCO-BRL) were pelleted and resuspended in 1,5 mL cold PBS1...
ORGANISM(S): Drosophila melanogaster 
2009-10-12 | E-MEXP-1556 | biostudies-arrayexpress
UnknownDifferential effects and interactions of endogenous and horizontally acquired H-NS-like proteins in pathogenic Escherichia coli.
Not available
S-EPMC2814080 | biostudies-literature
TranscriptomicsRNAi profiling of Drosophila Schneider S2 cells treated with dsRNA vs. GFP
Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals that endogenous sma...
ORGANISM(S): Drosophila melanogaster 
2008-06-20 | E-GEOD-11370 | biostudies-arrayexpress
GenomicsChIP-Seq of fly Schneider S2 cells to investigate CID islands
The centromere-specific Histone H3-variant CENH3 (also known as CENP-A) is considered to be an epigenetic mark for establishment and propagation of centromere identity. Pulse-induction of CENH3 (Drosophila CID) in Schneider S2 cells incorporates into noncentromeric regions and generates CID islands ...
ORGANISM(S): Drosophila melanogaster 
2011-07-15 | E-MTAB-652 | biostudies-arrayexpress
ProteomicsConsequences of PNU 282987 treatment in GCs exposed to 1% O2 for 24 h
Previous studies suggested a role of acetylcholine (ACh) in the regulation of the ovary. A target receptor, alpha 7 nicotinic ACh receptor (CHRNA7; encoded by CHRNA7), is expressed in the human ovary, e.g. by stromal cells, oocytes and human granulosa cells (GCs). The objective of this study was to ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD059511 | Pride
Human ovary Inflammation Acetylcholine 
TranscriptomicsRNAi knock down of export factors in Drosphila Schneider cell lines
Six different endogenous Drosophila proteins (all potential export factors) have been inactivated using RNAi and leptomycin B (LMB) treatments. Five different endogenous Drosophila proteins (all potential export factors) have been targeted by RNAi. The effect on mRNA export is analyzed by monitoring...
ORGANISM(S): Drosophila melanogaster 
2003-05-15 | E-MEXP-4 | biostudies-arrayexpress
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