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Transcriptomicspulse labeling and fractionation of RNA after inhibition of miR-277 to detect transcriptional and post-transcriptional changes
Drosophila melanogaster Schneider cells (S2) were transfected with a 2'-O-methyl inhibitor antisense to miR-277 or an unrelated control sequence. Three days after inhibition of the miRNA, the cellular RNA was pulse-labeled with 4-thio-Uridine for 1 hour, then tthe cells were lysed and RNA was extrac...
ORGANISM(S): Drosophila melanogaster 
2013-11-25 | E-MEXP-3784 | biostudies-arrayexpress
TranscriptomicsIdentification and analysis of transgene-derived endo-siRNAs in Drosophila Schneider cells by Solexa sequencing.
Colonization of genomes by a new selfish genetic element is detrimental to the host species and must lead to an efficient, repressive response. In vertebrates as well as in Drosophila, piRNAs repress transposons in the germ line while endogenous siRNAs take on this role in somatic cells. For endo-si...
ORGANISM(S): Drosophila melanogaster 
2009-09-13 | E-GEOD-16958 | biostudies-arrayexpress
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsSkeletal muscle proteomics underpin multifaceted mitochondrial dysfunction in Friedreich´s Ataxia
Friedreich´s Ataxia (FRDA) is a severe neuromuscular disorder caused by a deficiency of the mitochondrial protein frataxin. While some aspects of FRDA pathology are developmental, the causes underlying the steady progression are unclear. The inaccessibility of key affected tissues to sampling is a m...
ORGANISM(S): Homo sapiens (Human) 
2023-12-04 | PXD044554 | Pride
Friedreich´s ataxia Skeletal muscle Mitochondria Frataxin 
UnknownTowards Self-regenerating Antimicrobial Polymer Surfaces.
Not available
S-EPMC4968630 | biostudies-literature
UnknownToward an electrophysiological "sweet spot" for deep brain stimulation in the subthalamic nucleus.
Not available
S-EPMC6867148 | biostudies-literature
TranscriptomicsQuality control of spliced mRNAs requires the shuttling SR-proteins Gbp2 and Hrb1
Eukaryotic cells have to prevent the export of unspliced pre-mRNAs until intron removal is completed to avoid the expression of aberrant and potentially harmful proteins. Only mature RNAs associate with the export receptor Mex67 (mammalian TAP) and enter the cytoplasm. The underlying nuclear quality...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-04 | E-GEOD-52808 | biostudies-arrayexpress
TranscriptomicsA small RNA response to DNA ends in Drosophila
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently reported DSB-induced RNAs (diRNAs) or Dicer and D...
ORGANISM(S): Drosophila melanogaster 
2012-08-03 | E-GEOD-38967 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML
Purpose: CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in cytogenetically normal AML (CN-AML). Patients and Methods: 467 homogeneously treated CN-AML patients were subdivided into ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15210 | biostudies-arrayexpress
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