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TranscriptomicsTranscription profiling of mouse lipopolysaccharide-induced inflammation in HFE-deficient and wild types
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is the anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron storage, resulting in low serum iron co...
ORGANISM(S): Mus musculus 
2004-03-15 | E-MEXP-95 | biostudies-arrayexpress
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
ProteomicsApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells
We compare the proteome of the brain endothelial cells obtained with the newly optimized protocol (iCE-BECs) to the primary human brain microvascular endothelial cells (HBMVECs) and the widely used immortalized brain endothelial cell line HCMECD3. The goal is to investigate the applicability of iCE-...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD062808 | Pride
Blood brain barrier Iron homeostasis Apoe4 Tfr 
TranscriptomicsStem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells
Gastric cancer is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with H. pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-42937 | biostudies-arrayexpress
TranscriptomicsExpression data from Ribonuclease Inhibitor (RI/Rnh1) deficient Human K562 cells
Summary: Ribonuclease Inhibitor (RI also known as Rnh1) is a 50 kDa, ubiquitously expressed leucine-rich repeat (LRR) protein. It is localized in cytosol and binds to pancreatic-type ribonucleases and inhibit their function. However, the entire biological role for Rnh1 is unknown. We generated RNH1...
ORGANISM(S): Homo sapiens 
2017-03-05 | E-MTAB-5162 | biostudies-arrayexpress
UnknownPerformance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia.
Not available
S-EPMC9877422 | biostudies-literature
UnknownA multinational Delphi consensus to end the COVID-19 public health threat.
Not available
S-EPMC9646517 | biostudies-literature
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Not available
S-EPMC6662613 | biostudies-literature
UnknownNew-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry.
Not available
S-EPMC10834159 | biostudies-literature
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