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GenomicsTranscriptional regulation by H3K122 acetylation in the lateral surface of the histone octamer
We characterize the acetylation of H3K122 for the first time. Towards this we mapped the genomic distribution of H3K122Ac, identified the enzyme introducing H3K122Ac, and addressed the functional contribution H3K122Ac to transcription. We found that H3K122Ac is associated with chromatin marks and ge...
ORGANISM(S): Homo sapiens 
2013-02-14 | E-GEOD-35954 | biostudies-arrayexpress
UnknownPatient involvement in treatment decisions is associated with increased therapy satisfaction in Hidradenitis suppurativa.
Not available
S-EPMC12440716 | biostudies-literature
UnknownThe Maudsley model of anorexia nervosa treatment for adolescents and emerging adults: A multi-centre cohort study.
Not available
S-EPMC12547371 | biostudies-literature
ProteomicsImpact of exercise on the proteome of human peripheral blood mononuclear cells
This project aimed to characterize the impact of high-intensity interval exercise (HIIE) vs. moderate-intensity continuous exercise (MICE) on immune cell proteomics. In a randomized crossover study with 23 young, recreationally active runners, we isolated peripheral blood mononuclear cells (PBMCs) b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-25 | PXD058573 | Pride
Exercise 
ProteomicsA targetable co-dependence of PI3Kα/δ and SUMO signaling in aggressive pancreatic cancer
The phosphatidylinositol-3-kinase (PI3K) signaling pathway plays a critical role in the biology and aggressive course of pancreatic ductal adenocarcinoma (PDAC), yet pharmacological PI3K targeting has not resulted in meaningful clinical success. Through genetic and pharmacological screenings, we ide...
ORGANISM(S): Homo sapiens (Human) 
2026-02-22 | PXD059116 | Pride
Phsphorylation Immunogenic cell death Sumoylation Tmt Pancreatic cancer Human Combination therapy Pi3k 
ProteomicsFrequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma (Global Proteome and PPI)
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequen...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD034337 | Pride
Znf217 Pmbcl Non-hodgkin lymphoma Genetics Precision medicine Mutation Copy-number aberration 
ProteomicsFrequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma (Phospho-Proteome)
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequen...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040928 | Pride
Znf217 Phosphoproteome Pmbcl Non-hodgkin lymphoma Genetics Mutation 
UnknownExploring neurocognitive features in adolescents and young adults with anorexia nervosa: Evidence from a longitudinal study.
Not available
S-EPMC11617805 | biostudies-literature
UnknownAnti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.
Not available
S-EPMC5593507 | biostudies-literature
UnknownEarly mortality in atezolizumab/bevacizumab for HCC is associated with impaired liver function and alterations of systemic immunity.
Not available
S-EPMC12861967 | biostudies-literature
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