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TranscriptomicsIdentification and analysis of transgene-derived endo-siRNAs in Drosophila Schneider cells by Solexa sequencing.
Colonization of genomes by a new selfish genetic element is detrimental to the host species and must lead to an efficient, repressive response. In vertebrates as well as in Drosophila, piRNAs repress transposons in the germ line while endogenous siRNAs take on this role in somatic cells. For endo-si...
ORGANISM(S): Drosophila melanogaster 
2009-09-13 | E-GEOD-16958 | biostudies-arrayexpress
UnknownAURORA A interacts with DICER and SETD2 to promote S-phase progression
Not available
S-SCDT-10_1038-S44319-026-00850-0 | biostudies-other
ProteomicsPROTAC-triggered degradation of MYC
The oncogene MYC drives many cancers and is an outstanding therapeutic target. MYC is an intrinsically disordered protein, and therefore, targeting MYC remains a challenge. Here, we developed a proteolysis targeting chimera (PROTAC) degrading MYC: MDEG-541. The inhibitor is based on the MYC-MAX dim...
ORGANISM(S): Homo sapiens (Human) 
2022-05-12 | PXD018674 | Pride
Lc-ms3 Myc degradation Human 
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics-2
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-29 | MSV000093533 | MassIVE
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091043 | MassIVE
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
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