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TranscriptomicsComparison of spheroid-based 3-dimensional culture to monolayer of larynx carcinoma cell line HLaC78.
In vitro proliferation and/or invasion tests (such as MTT assay, Boyden Chamber Assay, Scratch assay) using established and well-characterized cell lines can provide easy and reproducible tools to investigate anti-tumour or anti-invasion agents ex vivo. However, in vivo cells in a tissue context int...
ORGANISM(S): Homo sapiens 
2016-03-11 | E-GEOD-67495 | biostudies-arrayexpress
TranscriptomicsmiRNA regulation in diabetes associated impaired wound healing
Circulating miRNAs constitute a novel class of disease biomarkers, which are altered in diabetes but the effect of diabetes associated inflammation as seen in chronic wounds is unknown. We here compared the miRNA pattern in diabetic patients in presence or absence of chronic wound with PAD. The clin...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-49885 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the cytosine methylation profile in Arabidopsis thaliana crown galls
Integration of the bacterial T-DNA into the plant genome by virulent agrobacteria causes crown gall development on many plant species. Plant tumor development shares fundamental similarities with mammalian cancer progression despite obvious differences in initiation of tumor development. For neoplas...
ORGANISM(S): Arabidopsis thaliana 
2013-02-18 | E-GEOD-37680 | biostudies-arrayexpress
TranscriptomicsEffect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of children with a prevalence of 5-10% worldwide. Up to 30% of adults with a history of childhood ADHD maintain symptoms in later life; these adult ADHD patients are severely impaired in social and professional life d...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-52889 | biostudies-arrayexpress
TranscriptomicsPrenatal stress-induced programming of genome-wide promoter DNA methylation in 5-Htt deficient mice
The serotonin transporter (5-HTT) gene-linked polymorphic region has been suggested to play a modulatory role in mediating the effects of early-life stress on psychopathology rendering carriers of the low-expression short (s)-allele more vulnerable to environmental adversity in later life. Here we a...
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-51634 | biostudies-arrayexpress
TranscriptomicsSex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life ...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-26025 | biostudies-arrayexpress
UnknownMacrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing.
Not available
S-EPMC6291261 | biostudies-literature
TranscriptomicsMethylation profiling of the chimpanzee CNTNAP2 gene in brain using high-resolution tiling arrays.
Accelerated brain development is a unique feature of the human species. Not only the size but also morphology, in particular the connections between frontal cortex and basal ganglia distinguish the human brain from great apes and other primates. Recent findings suggest that structural features which...
ORGANISM(S): Pan troglodytes 
2014-02-20 | E-GEOD-52949 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of the human CNTNAP2 gene in brain using high-resolution tiling arrays.
Accelerated brain development is a unique feature of the human species. Not only the size but also morphology, in particular the connections between frontal cortex and basal ganglia distinguish the human brain from great apes and other primates. Recent findings suggest that structural features which...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-52948 | biostudies-arrayexpress
TranscriptomicsActivation of myenteric glia during acute inflammation in vitro
Enteric glial cells (EGCs) are the main constituent of the enteric nervous system and share similarities with astrocytes from the central nervous system including their reactivity to an inflammator microenvironment. In this study we isolated GFAP-positive myenteric glia from FVB/hGFAP-eGFP transgeni...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-78015 | biostudies-arrayexpress
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