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TranscriptomicsEffects of diet and age on canine cerebral cortex gene expression
Mechanisms contributing to age-related cognitive decline are poorly defined. Thus, we used canine microarrays to compare gene expression profiles of brain tissue from geriatric and young adult dogs. Cerebral cortex samples were collected from 6 geriatric (12 yr-old) and 6 young adult (1 yr-old) fe...
ORGANISM(S): Canis lupus familiaris 
2008-08-05 | E-GEOD-12328 | biostudies-arrayexpress
TranscriptomicsEffects of diet and age on canine liver gene expression
The liver is the central organ in the regulation of nutrient metabolism, xenobiotic metabolism, and detoxification. Aging leads to a marked change in liver structure and function, characterized by a decline in weight, blood flow, regeneration rate, and detoxification. However, the mechanisms that ...
ORGANISM(S): Canis lupus familiaris 
2011-01-01 | E-GEOD-22945 | biostudies-arrayexpress
TranscriptomicsEffects of diet and age on canine colon tissue gene expression
Aging alters gastrointestinal morphology, microbiota, and functionality, and is associated with increased incidence of intestinal disease. The mechanisms that contribute to these changes are poorly described. Gene expression in dogs has been evaluated for a few select genes under pathogenic or var...
ORGANISM(S): Canis lupus familiaris 
2010-08-01 | E-GEOD-20557 | biostudies-arrayexpress
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