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TranscriptomicsStimulation of BL2 cell line with lipopolysaccharide (LPS) for 6h
Identification of genes up or down regulated in LPS stimulated samples in comparison to control samples. 3 LPS stimulated samples vs. 3 controls were analyzed
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29700 | biostudies-arrayexpress
TranscriptomicsLMP2A mediated gene expression changes in transfected CD10+ GCB cells
In this study, we have investigated the effect of LMP2A on gene expression in normal human GC B cells using a non-viral vector based system Keywords: transfection of viral oncogene in normal human B cells Gene expression was compared between LMP2A-transfected and control vector-transfected GC B cell...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-46143 | biostudies-arrayexpress
TranscriptomicsDown-regulation of BLIMP1-alpha by the EBV oncogene, LMP1, disrupts the plasma cell differentiation program and prevents viral replication in B cells
In this study, we have investigated the effect of BLIMP1α on gene expression, cell differentiation and pathogenesis in normal human GC B cells using a non-viral vector based system Gene expression was compared among BLIMP1α, LMP1-transfected and control vector-transfected GC B cells from two patient...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-27670 | biostudies-arrayexpress
TranscriptomicsHigh Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas
In this study we investigated to which extend aberrant c Myc activity plays a functional role in other aNHL and whether it is independent from MYC translocations. Based on a combined microarray analysis of human germinal centre (GC) B cells transfected with c Myc and 220 aNHLs cases, we developed a ...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-31311 | biostudies-arrayexpress
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
TranscriptomicsBL2 cells stimulated with B cell specific paracrine stimuli
Expression data of BL2 Burkitt Lymphoma cell line (controls and samples treated with different B cell specific stimuli) BL2 cells were cultured in RPMI and stimulated with the respective agents (rhCD40L, rhIL21, rhBAFF, LPS and antiIgM F(ab) fragments) for indicated timepoints. Cells were harvested ...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-42660 | biostudies-arrayexpress
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