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TranscriptomicsExon-level analyses of neuroblastoma
In this study, mRNA expression profiles of 113 primary untreated human neuroblastoma samples were compared with the aim to identify prognostic exon and gene sets as well as parameters associated with alternative exon use. The primary neuroblastoma specimens were from tumor banks in Cologne or Essen,...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-32664 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human medulloblastoma cell line ONS76 upon siRNA-mediated knockdown of KDM5A/LSD1
KDM5A/LSD1 is an important epigenetic regulator in medulloblastoma, the most frequent brain tumor of childhood. Here, the response of ONS76 medulloblastoma cells upon siRNA-mediated knockdown of KDM5A is analysed. The expression profile of ONS76 cells upon KDM5A knockdown was compared to mock contro...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43552 | biostudies-arrayexpress
TranscriptomicsBone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investi...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-22139 | biostudies-arrayexpress
GenomicsRelapsed and Primary Neuroblastoma DAC
Data Access Committee EGAC00001000373
EGAC00001000373 | EGA
TranscriptomicsExpression profiling of the murine neural crest precursor cell line, JoMa1
JoMa1 cells are pluripotent precursor cells, derived from the neural crest of mice transgenic for tamoxifen-inducible c-Myc. Following transfection with a cDNA encoding for MYCN, cells become immortlized even in the absence of tamoxifen. The expression profile of JoMa1 cells was compared to cell lin...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-27159 | biostudies-arrayexpress
UnknownHistamine plasma levels from dietary histidine/histamine intake correlate with CGRP in trigeminal tissues.
Not available
S-EPMC12616900 | biostudies-literature
TranscriptomicsComprehensive genomic analysis of relapse neuroblastoma [gene expression]
Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. Here we describe the expression data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-65303 | biostudies-arrayexpress
TranscriptomicsExpression profiling tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition
Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-57810 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine neuroblastoma in transgenic mice
Neuroblastoma is an embryonal tumor arising from the neural crest. It can be mimicked in mice by neural crest-specific overepxression of oncogenes such as MYCN or mutated ALK. Expression profiling of murine neuroblastoma driven by MYCN were compared to those driven by mutated ALK and to mouse normal...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-32386 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine MYCN-driven neuroblastomas from LSL-MYCN; Dbh-iCre mice.
Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a transgenic mouse with Cre-conditional induction of MYCN in dopamine beta hydroxylase expressing cells that develops murine neuroblastomas. The e...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51297 | biostudies-arrayexpress
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