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TranscriptomicsExpression data of Arabidopsis thaliana wild-type plants and quadruple nas T-DNA insertion mutants grown under different Fe supply conditions
Essential metals such as iron are required for healthy plant growth. Fe is an important cofactor and catalytic element in many biological processes. Fe and other metals can also be toxic when present in excess. Therefore plants have mechanisms of metal homeostasis which involve coordination of metal...
ORGANISM(S): Arabidopsis thaliana 
2010-09-25 | E-GEOD-24348 | biostudies-arrayexpress
ProteomicsGiant Axonal Neuropathy (GAN): Cross-sectional data on phenotypes, genotypes and proteomics signature from a German-Austrian-Swiss cohort
Giant Axon Neuropathy (GAN) is a progressive neurodegenerative disease characterised by involvement of peripheral and central nervous system frequently associated with frizzy hair. The phenotype is caused by bi-allelic variants in the GAN gene, leading to loss of functional gigaxonin proteins.. Thus...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053070 | Pride
White blood cells Gan Proteomics 
TranscriptomicsHLA ligand profiles of primary renal cell carcinoma maintained in metastases.sue
In recent years, several approaches have been taken in the peptide-based immunotherapy of metastatic renal cell carcinoma (RCC), although little is known about HLA presentation on metastases compared to primary tumor and normal tissue of RCC. In this study we compared primary tumor, normal tissue an...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12606 | biostudies-arrayexpress
ProteomicsAssociation of heme-bound HRI with S-DELE1 promotes HRI auto-phosphorylation
This dataset assesses the effects of S-DELE1 association on the auto-phosphorylation of human, heme-bound HRI. Human HRI and DELE1 were expressed in EIF2alpha-phospho-resistant cells supplemented with hemin. HRI was affinity purified, the elution subjected to denaturing gel electrophoresis, and HRI...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD062916 | Pride
TranscriptomicsPeritoneal and testicular macrophage mrna expression after exposure to UPEC CFT073
Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways...
ORGANISM(S): Rattus norvegicus 
2010-10-20 | E-GEOD-24780 | biostudies-arrayexpress
TranscriptomicsIn vitro transcriptional profiling of dendritic cells treated with Denileukin diftitox (ONTAK)
In order to assess the transcriptional modifications of dendritic cells treated with Denileukin diftitox (ONTAK), we profiled the whole transcriptome of monocyte-derived dendritic cells (moDC) from blood of healthy volounteers after stimulation with a maturation cocktail with or without the addition...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-MTAB-979 | biostudies-arrayexpress
TranscriptomicsTreatment of dendritic cells and monocytes from immunotherapy treated patients with ONTAK
In this experiment, dendritic cells and monocytes obtained from melanoma patients who underwent immunotherapy were stimulated with a maturation cocktail then either treated or not treated with denlieukin diftitox (DD; ONTAK) and then subjected to transcription profiling to investigate the effects of...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-MTAB-977 | biostudies-arrayexpress
UnknownCheckpoint kinase 1 is essential for fetal and adult hematopoiesis
Not available
S-SCDT-EMBOR-2018-47026V1 | biostudies-other
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
UnknownChronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy
Not available
S-SCDT-10_1038-S44319-024-00160-3 | biostudies-other
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