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ProteomicsCell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice
Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effect...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-20 | PXD020744 | Pride
Innate immunity Acute-phase response Il-6 Gp130 
GenomicsDissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors
Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...
EGAS00001001752 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:01:24:124-96 - samples
RNAseq on Illumina HiSeq2000/2500 of WNT reporter of PDO culture derived from colorectal cancer metastasis sample
EGAD00001002074 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:08:19:631-106 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer metastasis sample
EGAD00001002084 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:21:37:629-120 - samples
Whole-exome sequencing on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample
EGAD00001002098 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:25:47:437-127 - samples
Whole-exome sequencing on AB 5500xl Genetic Analyzer of colorectal cancer metastasis sample
EGAD00001002105 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:10:37:045-110 - samples
Whole-genome sequencing on Illumina HiSeq2000/2500 of colorectal cancer primary tumor sample
EGAD00001002088 | EGA
Genomicsena-DATASET-MPIMG-15-06-2017-11:16:33:021-1359 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from colorectal cancer metastasis sample (OT2_cohort)
EGAD00001003366 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:05:07:941-101 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from PDO culture derived from colorectal cancer primary tumor sample
EGAD00001002079 | EGA
Genomicsena-DATASET-MPIMG-04-05-2016-11:02:16:013-97 - samples
RNAseq on Illumina HiSeq2000/2500 of Patient-derived xenograft derived from PDO culture derived from colorectal cancer metastasis sample
EGAD00001002075 | EGA
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