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MetabolomicsEffects of GP130 Antagonism on Right Ventricular Metabolism in Monocrotaline Rats
Not available
ORGANISM(S): Rattus norvegicus 
ST001870 | MetabolomicsWorkbench
TranscriptomicsFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by the elevated expression of inflammatory proteins in tumour hepatocytes1,2. Here we show a striking activation of the IL6 signalling pathway in this tumour type, and sequenc...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-11819 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of SNS-gp130-/- vs control mice
To analyze the effect of Glycoprotein 130 in small diameter sensory neurons, dorsal root ganglia (DRG) of conditional SNS-gp130-/- and control (gp130fl/fl) mice were collected and mRNA expression profiles were compared between the two groups. DRG samples of two littermate mice were always pooled and...
ORGANISM(S): Mus musculus 
2014-08-04 | E-MTAB-2584 | biostudies-arrayexpress
ProteomicsEffect of GP130 Antagonism on Microtubule Associated Proteins
TMT10plex analysis of microtubule associated proteins from right ventricular extracts of 3 control rats, 3 monocrotaline rats, and 4 monocrotaline rats treated with the GP130 antagonist SC144.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2021-07-19 | MSV000087852 | MassIVE
TranscriptomicsGp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways
Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure tissue specific responses after proinflammatory stimulus with IL-6 across different time points. We ...
ORGANISM(S): Mus musculus 
2010-11-13 | E-GEOD-25278 | biostudies-arrayexpress
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
ProteomicsCell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice
Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effect...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-20 | PXD020744 | Pride
Innate immunity Acute-phase response Il-6 Gp130 
GenomicsGP130 Antagonism in Porcine RV Failure
GP130 Antagonism in Porcine RV Failure
PRJNA1215936 | ENA
TranscriptomicsTranscription profiling of mouse pressure overload induced cardiomyopathy in gp130 knock-out mice
Comparison between wild-type and cardiomyocyte-restricted knock-out of IL6 cytokines receptor component gp130 after surgical intervention for pressure-overload induced cardiomyopathy.
ORGANISM(S): Mus musculus 
2004-06-30 | E-MEXP-104 | biostudies-arrayexpress
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