Sort   by:  
 Page size 
UnknownCorrelations in sleeping patterns and circadian preference between spouses.
Spouses may affect each other's sleeping behaviour. In 47,420 spouse-pairs from the UK Biobank, we found a weak positive phenotypic correlation between spouses for self-reported sleep duration (r = 0.11; 95% CI = 0.10, 0.12) and a weak inverse correlation for chronotype (diurnal preference) (r = -0....
S-EPMC10643442 | biostudies-literature
UnknownMyocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial.

Background

There are currently limited data on the relationships between resting perfusion abnormalities, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, and exercise capacity as defined by peak VO(2) and 6-minute walk test in patients with hear...
S-EPMC2908486 | biostudies-literature
UnknownInvestigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics.
Growing evidence from both epidemiology and basic science suggest an inverse association between Alzheimer's disease (AD) and cancer. We examined the genetic relationship between AD and various cancer types using GWAS summary statistics from the IGAP and GAME-ON consortia. Sample size ranged from 99...
S-EPMC5693762 | biostudies-literature
UnknownThe relationship between body mass index and cardiopulmonary exercise testing in chronic systolic heart failure.

Background

Cardiopulmonary exercise testing (CPX) in patients with systolic heart failure (HF) is important for determining HF prognosis and helping guide timing of heart transplantation. Although approximately 20% to 30% of patients with HF are obese (body mass index [BMI] >30 kg/m(2)), the...
S-EPMC2762950 | biostudies-literature
UnknownN-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study.

Objectives

To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure.

Background

Natriuretic peptides such as NT-proBNP are important biomarkers in heart failure....
S-EPMC3748954 | biostudies-literature
UnknownUsing a polygenic score in a family design to understand genetic influences on musicality.
To further our understanding of the genetics of musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGSrhythm) and objectively measured rhythm discrimination, as well as other validated music skills and music-related traits. Using...
S-EPMC9424203 | biostudies-literature
UnknownComprehensive molecular profiling of lung adenocarcinoma.
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were see...
S-EPMC4231481 | biostudies-literature
UnknownThe Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

Importance

Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.

Objectiv...

S-EPMC8482304 | biostudies-literature
UnknownCADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) of eight impulsive personality traits from the...
S-EPMC10182097 | biostudies-literature
ProteomicsADAMTS12 serves as a checkpoint in fibrosis that controls migration and expansion of injury-responsive fibroblasts
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-sequencing (scRNA-seq) technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD040152 | Pride
Fibrosis Adamts12 Extracellular matrix 
Sort   by:  
 Page size