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UnknownRisk Factors for Cardiac and Non-cardiac Causes of Death in Males with Duchenne Muscular Dystrophy.
As survival and neuromuscular function in Duchenne muscular dystrophy (DMD) have improved with glucocorticoid (GC) therapy and ventilatory support, cardiac deaths are increasing. Little is known about risk factors for cardiac and non-cardiac causes of death in DMD. A multi-center retrospective cohor...
S-EPMC7328368 | biostudies-literature
UnknownUse of advanced heart failure therapies in Duchenne muscular dystrophy.

Background

As survival and neuromuscular function in Duchenne Muscular Dystrophy (DMD) improve with glucocorticoid therapy and respiratory advances, the proportion of cardiac deaths is increasing. Little is known about the use and outcomes of advanced heart failure (HF) therapies in this pop...
S-EPMC6663084 | biostudies-literature
UnknownAssociation of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study.

Background

Multiple primary cancers account for approximately 16% of all incident cancers in the United States. Although genome-wide association studies (GWAS) have identified many common genetic variants associated with various cancer sites, no study has examined the association of these ge...
S-EPMC4221293 | biostudies-literature
Unknown20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.

Background

The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side e...
S-EPMC5734609 | biostudies-literature
UnknownExposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study.

Background

The ongoing West African Ebola epidemic began in December 2013 in Guinea, probably from a single zoonotic introduction. As a result of ineffective initial control efforts, an Ebola outbreak of unprecedented scale emerged. As of 4 May 2015, it had resulted in more than 19,000 proba...
S-EPMC5112802 | biostudies-literature
UnknownHeme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.
The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport cha...
S-EPMC5650512 | biostudies-literature
UnknownCAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.

Objective

Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG repeat allele has been reported also to influence age at onset, in interaction with the expanded allele. Due to ...
S-EPMC3306163 | biostudies-literature
UnknownEffect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials.

Background

Postmastectomy radiotherapy was shown in previous meta-analyses to reduce the risks of both recurrence and breast cancer mortality in all women with node-positive disease considered together. However, the benefit in women with only one to three positive lymph nodes is uncertain. W...
S-EPMC5015598 | biostudies-literature
UnknownRelevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials.

Background

As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamo...
S-EPMC3163848 | biostudies-literature
UnknownEffect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials.

Background

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and r...
S-EPMC3254252 | biostudies-literature
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