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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsTranscription profiling of whole adult mouse and adult mouse colon in different dilutions analysed in multiple centers
This data is part of a large-scale platform comparison experiment. Whole mouse and adult mouse colon RNA was mixed at different concentrations (100:0, 75:25, 50:50, 25:75, and 0:100) and distributed across multiple centers for analysis. Eight microarray platforms and RT-PCR were tested for differe...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2850 | biostudies-arrayexpress
UnknownMolybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase.
Not available
S-EPMC9474665 | biostudies-literature
UnknownThe Acetabular Wall Index Is Associated with Long-term Conversion to THA after PAO.
Not available
S-EPMC8052033 | biostudies-literature
UnknownCrystallization of the novel S-adenosyl-L-methionine-dependent C-methyltransferase CouO from Streptomyces rishiriensis and preliminary diffraction data analysis.
Not available
S-EPMC3370914 | biostudies-literature
ProteomicsTranscriptome and proteome profiles of the diazotroph Nitrospirillum amazonense strain CBAmC in response to the sugarcane apoplast fluid
The diazotrophic CBAmC strain of Nitrospirillum amazonense has been reported to promote growth of sugarcane variety RB867515 when inoculated under field conditions in a consortium with four other nitrogen-fixing bacteria. The present work had the objective of accessing the influence of the sugarcane...
ORGANISM(S): Nitrospirillum amazonense CBAmc 
2019-07-12 | PXD013518 | Pride
Transcripts  proteins  bacteria-plant interaction  saccharum spp. 
ProteomicsAquifer metaproteomics - Candidate Brocadiales dominates C, N and S cycling in anoxic groundwater of a pristine limestone-fracture aquifer
Groundwater-derived microorganisms are known to play an important role in biogeochemical C, S and N cycling. Thereby, the presence and majorly the activity of microorganisms in aquifers affect enormously the nutrient cycling. However, the diversity and their functional capability in natural aquifers...
ORGANISM(S): Escherichia coli 
2016-12-23 | PXD004351 | Pride
Microbial community Groundwater Metaproteomics 
UnknownOne-pot synthesis of 4-pyrimidone-2-thioether through base/acid-mediated condensation of S-alkylisothiourea and β-ketoester† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4ra00039k
Not available
S-EPMC10862098 | biostudies-literature
UnknownThe New Bern Chondrolabral Classification Is Reliable and Reproducible.
Not available
S-EPMC8083824 | biostudies-literature
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