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TranscriptomicsTranscription profiling of mouse liver to identify the effect of intermittent hypoxia on gene expression in the liver of ob/ob mice
All animals were kept in a controlled environment (22-24 °C with a 12 h : 12 h light : dark cycle; lights on at 09.00) on a standard chow diet with free access to water. Five ob/ob mice (sample_ids GSM32865-GSM32869) were placed in the intermittent hypoxia (IH) chamber and subjected to IH for 12 con...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-1873 | biostudies-arrayexpress
GenomicsSporadic autism exomes reveal a highly interconnected protein network of de novo mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482.v1.p1 | EGA
UnknownA novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.
Not available
S-EPMC5986604 | biostudies-literature
TranscriptomicsThe Role of the E2F1 transcription factor in the innate immune response to systemic LPS [mRNA]
Our recent study of gene expression in mice treated with LPS systemically identified the E2F1 transcription factor as a novel regulator of innate immune response in lung, liver, and spleen tissue. Our follow up studies showed that RNAi-mediated inhibition or E2F1 gene deficiency lead to reduced infl...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-33901 | biostudies-arrayexpress
TranscriptomicsThe Role of the E2F1 transcription factor in the innate immune response to systemic LPS [miRNA]
Our recent study of gene expression in mice treated with LPS systemically identified the E2F1 transcription factor as a novel regulator of innate immune response in lung, liver, and spleen tissue. Our follow up studies showed that RNAi-mediated inhibition or E2F1 gene deficiency lead to reduced infl...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-33900 | biostudies-arrayexpress
TranscriptomicsPulmonary innate immune response to ozone and TLR2 agonist Pam3CYS in C57BL/6 mice
Rationale: Previous work demonstrated that pre-exposure to ozone primes innate immunity and increases TLR4-mediated response to subsequent stimulation with lipopolysaccharide (LPS). To further explore the pulmonary innate immune response to ozone exposure, we investigated the effect of ozone in com...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-38014 | biostudies-arrayexpress
UnknownWorldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2).
Not available
S-EPMC6195190 | biostudies-literature
UnknownThe histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).
Not available
S-EPMC6195192 | biostudies-literature
UnknownWorldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries.
Not available
S-EPMC5418564 | biostudies-literature
UnknownGlobal surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2).
Not available
S-EPMC4588097 | biostudies-literature
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