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TranscriptomicsUltra-deep sequencing of plasma DNA identifies druggable mutations in hepatocellular carcinoma
The purpose of the study is to detect somatic mutations in hepatocellular carcinoma using circulating free-DNA. We used deep-sequencing data of a panel of 60 commonly mutated genes in hepatocellular carcinoma.
ORGANISM(S): Homo sapiens 
2018-04-29 | E-MTAB-5123 | biostudies-arrayexpress
TranscriptomicsDNA copy number profiles of formalin-fixed, paraffin-embedded human intrahepatic cholangiocarcinoma
BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can be classified as intrahepatic (ICC) or extrahepatic. We performed an integrative genomic analysis of ICC samples from a large series of patients. METHODS: We performed gene expression profile, high-density single nucleot...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-33326 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of formalin-fixed, paraffin-embedded human intrahepatic cholangiocarcinoma
BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can be classified as intrahepatic (ICC) or extrahepatic. We performed an integrative genomic analysis of ICC samples from a large series of patients. METHODS: We performed gene expression profile, high-density single nucleot...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-32225 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human liver samples from HCV-induced dysplasia and hepatocellular carcinoma patients, progression study
Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accur...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6764 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of human hepatocellular carcinoma
microRNA profiling of 89 human hepatocellular carcinoma tissues using bead-based technology. microRNA expression profiling was performed using freshly frozen hepatocellular carcinoma tissues obtained at the time of surgical treatment.
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20594 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line
mRNA expression profile modified by stable transfection of microRNA mir-517a (MIR517A) in a human hepatocellular carcinoma cell line Huh-7 Keywords: Hepatocellular carcinoma, Expression array, microRNA microRNA mir-517a (MIR517A) was transfected to Huh-7 cells using GFP-expressing lentiviral vector...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20679 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of multiregional sampling in hepatocellular carcinoma
The purpose of this experiment is to characterize the intratumor heterogeneity in liver cancer and to study the crosstalk between the immune component of the tumor and the aberrant hepatocites.
ORGANISM(S): Homo sapiens 
2020-01-16 | E-MTAB-5905 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the human HCC cell line PLC5 after 72 hours treatment with either MAGEA3 shRNA or Scramble control
To better understand the mechanism by which MAGEA3 contributes to HCC progression, we conducted RNA sequencing in the PLC5 HCC cell line after 72 hours of treatment with scramble or sh8375 in triplicate. RNA-sequencing was conducted on poly-A enriched RNA, 100 bp single reads using an Illumina HiSeq...
ORGANISM(S): Homo sapiens 
2021-05-19 | E-MTAB-8860 | biostudies-arrayexpress
TranscriptomicsFocal gains of VEGFA and molecular classification of hepatocellular carcinoma
The data are derived from anonymized patient samples for which demographic information is not provided This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-06-22 | E-GEOD-9829 | biostudies-arrayexpress
TranscriptomicsCopy number alterations of 103 hepatocellular carcinomas with hepatitis C virus etiology
To characterize the genetic alterations that instigate hepatitis C virus-induced hepatocellular carcinoma (HCC), we conducted an integrative genomic analysis of 103 HCCs. Most tumors harbored 1q gain, 8q gain or 8p loss, with occasional alterations in 13 additional chromosome arms. In addition to ...
ORGANISM(S): Homo sapiens 
2008-06-21 | E-GEOD-9845 | biostudies-arrayexpress
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