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Proteomics,MultiomicsDynamic profiling of the protein life cycle in response to pathogens
Jovanovic M,Rooney M, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach M, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A, submitted 2015. Protein expression is regulated by production and degrada...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-01-15 | MSV000078994 | MassIVE
ProteomicsA sequence-specific RNA acetylation catalyst
N4-acetylcytidine (ac4C) is a ubiquitous RNA modification incorporated by cytidine acetyltransferase enzymes. Here, we report the biochemical characterization of Thermococcus kodakarensis Nat10 (TkNat10), an RNA acetyltransferase involved in archaeal thermotolerance. We demonstrate that TkNat10's ca...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-10-14 | MSV000096084 | MassIVE
TranscriptomicsHigh-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program [Hs]
N6-methyladenosine (m6A) is a common modification of mRNA, with potential roles in fine-tuning the RNA life cycle, but little is known about the pathways regulating this process and its physiological role. Here, we used mass-spectrometry to identify a dense network of proteins physically interacting...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-55572 | biostudies-arrayexpress
TranscriptomicsHigh-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program [Mm]
N6-methyladenosine (m6A) is a common modification of mRNA, with potential roles in fine-tuning the RNA life cycle, but little is known about the pathways regulating this process and its physiological role. Here, we used mass-spectrometry to identify a dense network of proteins physically interacting...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-55575 | biostudies-arrayexpress
TranscriptomicsHigh-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-54365 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (untreated)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells.
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37003 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide mapping reveals widespread dynamic regulated pseudouridylation of mRNA
Pseudouridine is the most abundant modification occurring on RNA, yet with the exception of a few well-studied RNA molecules little is known about the modified positions and their function(s). Here, we develop M-NM-(-seq, a method for transcriptome-wide quantitative mapping of pseudouridine. We vali...
ORGANISM(S): Candida albicans 
2014-09-11 | E-GEOD-60047 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (with treatments)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells. HepG2 cells were incubated with either IFNg (200ng/ml) o...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37002 | biostudies-arrayexpress
TranscriptomicsHigh-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
N6-methyladenosine (m6A) is the most ubiquitous mRNA base modification, but little is known about its precise location, temporal dynamics, and regulation. Here, we generated genomic maps of m6A sites in meiotic yeast transcripts at nearly single-nucleotide resolution, identifying 1,308 putatively me...
ORGANISM(S): Saccharomyces cerevisiae 
2013-11-22 | E-GEOD-51583 | biostudies-arrayexpress
TranscriptomicsmitoRibo-seq and RNA-seq of parental and MRM2 knockout HEK 293T Flp-In T-REx cells
Methyltransferase MRM2 methylates the 2’-hydroxyl group of ribonucleotide U1369 of human 16S mt-rRNA. Mutations in MRM2 have been implicated in human mitochondrial-related disease. This study investigates the role of MRM2 in the biogenesis and function of human mitochondrial ribosomes. Absence of MR...
ORGANISM(S): Homo sapiens 
2021-12-17 | E-MTAB-11292 | biostudies-arrayexpress
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