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UnknownDiabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions.
Not available
S-EPMC3837056 | biostudies-literature
UnknownCaffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes.

Background

A variant (rs1495741) in the gene for the N-acetyltransferase 2 (NAT2) protein is associated with skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation end products and other fluorophores in the skin. Because NAT2 is involved in caffeine metabolism, we aim...
S-EPMC4575521 | biostudies-literature
UnknownEpigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at specific loci over two different time points in people with diabetes are associated with metabolic memory, the prolonged beneficial effects of intensive vs. conventional therapy during the Diabetes Control and Comp...
S-EPMC4890596 | biostudies-literature
UnknownImpact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

Objective

Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is ...
S-EPMC5711332 | biostudies-literature
UnknownGlycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC.

Purpose

We examined the relationship between glycemic control and urinary tract infections in women with type 1 diabetes mellitus.

Materials and methods

Women enrolled in the Epidemiology of Diabetes Interventions and Complications study, the observational followup of the Diabetes Con...
S-EPMC5025347 | biostudies-literature
UnknownDNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes.

Background

Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal ...
S-EPMC7132894 | biostudies-literature
UnknownSerum urate and cardiovascular events in the DCCT/EDIC study.
In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, ...
S-EPMC8271014 | biostudies-literature
UnknownFrequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes.

Background

In patients who have had type 1 diabetes for 5 years, current recommendations regarding screening for diabetic retinopathy include annual dilated retinal examinations to detect proliferative retinopathy or clinically significant macular edema, both of which require timely interven...
S-EPMC5557280 | biostudies-literature
UnknownIntensive diabetes therapy and ocular surgery in type 1 diabetes.

Background

The Diabetes Control and Complications Trial (DCCT) showed a beneficial effect of 6.5 years of intensive glycemic control on retinopathy in patients with type 1 diabetes.

Methods

Between 1983 and 1989, a total of 1441 patients with type 1 diabetes in the DCCT were randomly ...
S-EPMC4465212 | biostudies-literature
UnknownAssociation of genetic variation with age at diagnosis in type 1 diabetes.

Introduction

Type 1 diabetes is an autoimmune disease with a strong genetic basis. The aim of this study was to identify additional single-nucleotide polymorphisms (SNPs) for type 1 diabetes age at diagnosis and to replicate previously identified loci.

Research design and methods

Meta...
S-EPMC12815190 | biostudies-literature
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