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ProteomicsProteomic analysis of scleraxis mutant tendon
Tendons play fundamental role in the musculoskeletal system and locomotion by transferring forces generated by muscles to the skeleton. Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing and are among the leading causes of musculos...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD017944 | Pride
Scleraxis Tendon Lc-ms/ms 
GenomicsTranscriptional analysis of tenocytes from mice with a targeted deletion of scleraxis
Transcriptional analysis of tenocytes from mice with a targeted deletion of scleraxis
PRJNA608531 | ENA
ProteomicsScleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype
Aged tendons have disrupted homeostasis, increased injury risk, and impaired healing capacity. Understanding mechanisms of homeostatic disruption is crucial for developing therapeutics to retain tendon health through the lifespan. Here, we developed a novel model of accelerated tendon extracellular ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD037230 | Pride
Extracellular matrix Tendon Aging Mouse Scleraxis Lc-ms/ms 
GenomicsTranscriptional analysis of tendons from mice with a targeted deletion of scleraxis
Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis
PRJNA579978 | ENA
TranscriptomicsTranscriptional analysis of tendons from mice with a targeted deletion of scleraxis
We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus (Scx-). Mice in which scleraxis was deleted were created by crossing...
ORGANISM(S): Mus musculus 
2020-01-31 | GSE139493 | GEO
UnknownRegulation of Cardiac Fibroblast GLS1 Expression by Scleraxis.
Not available
S-EPMC9101234 | biostudies-literature
TranscriptomicsTranscriptional analysis of tenocytes from mice with a targeted deletion of scleraxis
We report RNA sequencing data from tenocytes cultured from the tail tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus using 4-hydroxytamoxifen (4HT).
ORGANISM(S): Mus musculus 
2020-02-24 | GSE145863 | GEO
UnknownScleraxis expressing scleral cells respond to inflammatory stimulation.
Not available
S-EPMC8397666 | biostudies-literature
UnknownScleraxis is required for the growth of adult tendons in response to mechanical loading.
Not available
S-EPMC7406294 | biostudies-literature
UnknownScleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.
Not available
S-EPMC6662971 | biostudies-literature
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